New trends for the medical treatment of endometriosis

Expert Opinion on Investigational Drugs
Ana Luiza L RochaFelice Petraglia

Abstract

Endometriosis is a benign sex hormone-dependent gynecological disease, characterized by the presence and growth of endometrial tissue outside the uterus; it affects 10% of women of reproductive age and is associated with infertility and pain. Treatment of endometriosis involves conservative or radical surgery, or medical therapies. The goals for endometriosis treatment may be the relief of pain and/or a successful pregnancy achievement in infertile patients. Treatment must be individualized with a multidisciplinary approach. The classical treatments carry adverse side effects and in some cases a negative impact on quality of life. New agents promise a distinct perspective in endometriosis treatment. The aim of this paper is to systematically review the literature evidence of new medical treatments for endometriosis, defined as pharmacological treatments not yet commonly available and currently under investigation. These new medical therapies would be used associated with surgical treatment and, in the future, will render possible the association of hormone therapy with non-hormonal treatment for endometriosis.

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Citations

Nov 14, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Carla N OlivaresGabriela F Meresman
Dec 5, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Patrizia CarrarelliFelice Petraglia
Dec 10, 2015·Expert Review of Clinical Pharmacology·Nicola PluchinoIsabelle Marie Streuli
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Jan 27, 2015·Human Reproduction Update·Mauricio Simões AbrãoCharles Chapron
Feb 19, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Zhixing JinZhiling Zhu
Aug 10, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Claudia TostiFelice Petraglia
Sep 7, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Ruihua ZhongYan Zhu
Sep 4, 2016·Human Reproduction Update·Nicola PluchinoFrancesco Bianchi-Demicheli
May 1, 2018·Expert Opinion on Investigational Drugs·Fabio BarraSimone Ferrero
Jul 6, 2018·Expert Opinion on Pharmacotherapy·Simone FerreroFabio Barra
Jul 1, 2014·Current Opinion in Obstetrics & Gynecology·Lieven Platteeuw, Thomas D'Hooghe
Jun 4, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Silvia VannucciniFelice Petraglia
May 7, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Mohummad Hasan Raza RajaRehana Rehman
May 20, 2021·Minerva Obstetrics and Gynecology·Simona MartoneStefano Luisi
Jul 3, 2021·Pharmaceuticals·Alexandre ValléeYves Lecarpentier
Aug 19, 2021·Reviews in Endocrine & Metabolic Disorders·Silvia VannucciniFelice Petraglia

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