New twists on long noncoding RNAs: from mobile elements to motile cancer cells.

RNA Biology
Tuan M NguyenJeffrey M Rosen

Abstract

The purpose of this review is to highlight several areas of lncRNA biology and cancer that we hope will provide some new insights for future research. These include the relationship of lncRNAs and the epithelial to mesenchymal transition (EMT) with a focus on transcriptional and alternative splicing mechanisms and mRNA stability through miRNAs. In addition, we highlight the potential role of enhancer e-lncRNAs, the importance of transposable elements in lncRNA biology, and finally the emerging area of using antisense oligonucleotides (ASOs) and small molecules to target lncRNAs and their therapeutic implications.

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Citations

Apr 2, 2021·Epigenetics & Chromatin·Yinyu WangHefeng Huang

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Methods Mentioned

BETA
antisense oligonucleotides
acetylation
pull away
GTPase
ubiquitination
CLIP
immunoprecipitation
-Seq
nuclear translocation

Software Mentioned

HOTAIR

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