New type non-lantibiotic bacteriocins: circular and leaderless bacteriocins

Beneficial Microbes
Yoshimitsu MasudaKenji Sonomoto

Abstract

Bacteriocins are antimicrobial peptides that are ribosomally synthesised by bacteria. Bacteriocins produced by Gram-positive bacteria, including lactic acid bacteria, are under focus as the next generation of safe natural biopreservatives and as therapeutic alternatives to antibiotics. Recently, two novel types of non-lantibiotic class II bacteriocins have been reported with unique characteristics in their structure and biosynthesis mechanism. One is a circular bacteriocin that contains a head-to-tail structure in the mature form, and the other is a leaderless bacteriocin without an N-terminal extension in the precursor peptide. A circular structure can provide the peptide with remarkable stability against various stresses; indeed, circular bacteriocins are known to possess higher stability than general linear bacteriocins. Leaderless bacteriocins are distinct from general bacteriocins, because they do not contain N-terminal leader sequences, which are responsible for the recognition process during secretion and for inactivation of bacteriocins inside producer cells. Leaderless bacteriocins do not require any post-translational processing for activity. These two novel types of bacteriocins are promising antimicrobial compounds,...Continue Reading

References

Jun 1, 1995·Journal of Bacteriology·R W WoroboM E Stiles
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·J N Hansen
Oct 1, 1996·Antonie van Leeuwenhoek·I F NesH Holo
Jan 21, 2000·FEMS Microbiology Reviews·S EnnaharA Ishizaki
Aug 10, 2000·Biopolymers·I F Nes, H Holo
May 12, 2001·FEMS Microbiology Reviews·O McAuliffeC Hill
Jan 5, 2002·International Journal of Food Microbiology·J ClevelandM L Chikindas
Jun 11, 2002·Journal of Molecular Biology·Daili Jacqueline Aguilar NetzHans-Georg Sahl
Nov 9, 2002·Biochimie·Sylvie GarneauJohn C Vederas
Feb 7, 2003·Applied and Environmental Microbiology·Marta DiazMercedes Maqueda
Mar 7, 2003·Applied and Environmental Microbiology·Robèr KempermanJan Kok
Mar 7, 2003·Applied and Environmental Microbiology·Marina Sánchez-HidalgoManuel Martínez-Bueno
Nov 17, 2004·Current Protein & Peptide Science·Yasushi KawaiTadao Saito
Nov 17, 2004·Current Protein & Peptide Science·Mercedes MaquedaEva Valdivia
Aug 2, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Gunnar FimlandJon Nissen-Meyer
Aug 10, 2005·Applied Microbiology and Biotechnology·Igor Mierau, Michiel Kleerebezem
Oct 6, 2005·Nature Reviews. Microbiology·Paul D CotterR Paul Ross
Jun 6, 2006·Applied and Environmental Microbiology·Antonio M Martín-PlateroManuel Martínez-Bueno
Jun 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Djamel DriderHervé Prévost
Apr 24, 2007·Journal of Applied Microbiology·M FernándezM Maqueda
Jul 7, 2007·International Journal of Food Microbiology·Antonio GálvezNabil Ben Omar
Aug 11, 2007·Bioscience, Biotechnology, and Biochemistry·Shun IwataniKenji Sonomoto
Sep 11, 2007·Journal of Molecular Microbiology and Biotechnology·Camilla OppegårdJon Nissen-Meyer
Oct 30, 2007·Cellular and Molecular Life Sciences : CMLS·J LubelskiO P Kuipers
Nov 24, 2007·FEMS Microbiology Reviews·Mercedes MaquedaManuel Martínez-Bueno
Jun 17, 2008·Applied and Environmental Microbiology·Leah A Martin-VisscherJohn C Vederas
Jun 24, 2008·Biochemistry·Gregory C PattonWilfred A van der Donk
Nov 18, 2008·Applied and Environmental Microbiology·Fuminori YoneyamaKenji Sonomoto

❮ Previous
Next ❯

Citations

Feb 28, 2014·Trends in Microbiology·Teresa M BergholzMartin Wiedmann
Sep 5, 2014·Microbial Cell Factories·Rodney H PerezKenji Sonomoto
Feb 11, 2016·Applied Microbiology and Biotechnology·Patricia Alvarez-SieiroOscar P Kuipers
Aug 8, 2018·FEMS Microbiology Reviews·Jeella Z AcedoMarco J van Belkum
Aug 26, 2014·Applied and Environmental Microbiology·Naoki IshibashiKenji Sonomoto
Nov 6, 2015·Journal of Applied Microbiology·Yoshimitsu MasudaKenji Sonomoto
Sep 21, 2018·Frontiers in Microbiology·Rodney H PerezKenji Sonomoto
Jan 28, 2021·International Journal of Molecular Sciences·Aleksandra Tymoszewska, Tamara Aleksandrzak-Piekarczyk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Biomaterial Engineering

Advances in biomaterial engineering have permitted the development of sophisticated drug-releasing materials with a biomimetic 3D support that allow a better control of the microenvironment of transplanted cells. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.