New type of antibody-enzyme conjugate which specifically kills Candida albicans.

Infection and Immunity
K OkudaI Tadokoro

Abstract

A new type of antibody-enzyme conjugate was made, and its possible application to Candida infection was studied. Both lactoperoxidase and xanthine oxidase were conjugated to specific antibody against Candida albicans. In vitro microbiocidal activity of the new antibody-enzyme conjugate, when incubated together with xanthine and minute amount of halides, showed a remarkable level of candidacidal ability. When the new antibody-enzyme conjugate was given to Candida-infected mice, followed by injecting xanthine and a minute amount of halides, about 50% of these heavily infected mice survived, whereas all control nontreated mice died. These data suggest that the further eleboration of this new antibody-enzyme conjugate might lead us to improve our therapeutic methods of clinical medicine.

References

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Citations

Sep 1, 1990·DNA and Cell Biology·T J DullJ J Seilhamer
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·C F Nathan
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Feb 1, 1985·Infection and Immunity·C D Wright, R D Nelson

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