New vaccines against tuberculosis

Tropical Medicine & International Health : TM & IH
T Mark Doherty

Abstract

In September 2000, recognizing the effect of communicable diseases as obstacles to development in poorer countries, the European Commission assembled a special round table on 'accelerated action targeted at major communicable diseases within the context of poverty reduction'. The three major communicable diseases discussed were tuberculosis (TB), malaria and HIV. One outcome of this discussion was a workshop examining issues related to the fight against TB in Africa, which took place in Gorée, Sénégal, in May 2001. The timing was propitious, as new vaccines for TB (recombinant MVA and BCG, and adjuvanated recombinant fusion proteins or peptide constructs), are just beginning to enter human clinical trials. All but the last of these have shown promise in animal models, up to and including non-human primates, and all are strongly immunogenic and apparently safe. Humans trials for safety and efficacy are thus the logical next step. This review summarizes recent advances in tuberculosis vaccine development, with a special emphasis on issues raised at the Gorée meeting about testing and deploying new generation vaccines in TB-endemic areas such as Africa.

References

Dec 1, 1993·The Journal of Experimental Medicine·J L FlynnB R Bloom
Dec 1, 1993·The Journal of Experimental Medicine·A M CooperI M Orme
Sep 20, 1997·Nature·M A Behr, P M Small
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·M M Tala-HeikkiläE O Tala
Feb 10, 1999·The Journal of Infectious Diseases·P RavnP Andersen
Jul 27, 1999·Nature·D B LowrieC L Silva
Jan 20, 2000·Infection and Immunity·L BrandtP Andersen
Feb 7, 2001·The New England Journal of Medicine·W W Stead, J H Bates
Sep 1, 1996·Indian Journal of Pediatrics·S K MittalN Saini
Aug 26, 2000·Cytokine & Growth Factor Reviews·S E Dorman, S M Holland
Sep 29, 2000·Lancet·P AndersenT M Doherty
Sep 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D SmithV Balasubramanian
Feb 13, 2001·American Journal of Respiratory Cell and Molecular Biology·J TurnerA M Cooper
Mar 20, 2001·Infection and Immunity·J V BrooksI M Orme
Apr 3, 2001·American Journal of Respiratory and Critical Care Medicine·A LalvaniA V Hill
Apr 5, 2001·Trends in Molecular Medicine·D N McMurray
Jun 13, 2001·Infection and Immunity·N V Serbina, J L Flynn
Jun 19, 2001·Biological Chemistry·H MollenkopfS H Kaufmann
Jul 7, 2001·Scandinavian Journal of Infectious Diseases·P Nunn
Jul 27, 2001·The Journal of Infectious Diseases·P G SuárezC Dye
Aug 3, 2001·Vaccine·A S De GrootC Saint-Aubin
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D H CanadayW H Boom
Aug 23, 2001·Scandinavian Journal of Infectious Diseases·S Stenger
Mar 2, 2002·The Lancet Infectious Diseases·H L Collins, S H Kaufmann
Feb 7, 2003·Current Pharmaceutical Biotechnology·Limei Meng OkkelsPeter Andersen
Apr 15, 2003·Nature Medicine·Alexander S PymStewart T Cole

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Citations

Feb 6, 2009·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Manikandan KaruppasamyManfred S Weiss
Oct 29, 2005·Tuberculosis·Nico J D NagelkerkeMartien Borgdorff
May 12, 2005·Health Affairs·Sarah Landry, Carole Heilman
Apr 9, 2005·Current Opinion in Pulmonary Medicine·Rosemary J Boyton
Aug 25, 2005·Expert Review of Vaccines·Marien I de JongeStewart T Cole
Apr 8, 2009·Mycopathologia·Estefânia Mara do Nascimento MartinsAlfredo Miranda Goes

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