New Vascular Graft Using the Decellularized Human Chorion Membrane.

ACS Biomaterials Science & Engineering
Laura P FrazãoNuno M Neves

Abstract

The increase of both arterial occlusive diseases and coronary heart diseases leads to a higher demand for small-diameter vascular grafts (<6 mm). The gold standard for small-diameter vessel replacement is the use of autologous veins. Nevertheless, up to 30% of these patients need to use vascular grafts. Although synthetic polymers have been successfully used for the replacement of large-diameter vascular grafts (>6 mm), they are associated with thrombosis, intimal hyperplasia, calcification, and chronic inflammation when used as small-diameter vascular grafts. Therefore, natural materials have been studied for this application. In this study, a decellularized human chorion membrane (dHCM) vascular graft with a 3-4 mm diameter was created. Herein, the biocompatibility of dHCM with endothelial cells was demonstrated in vitro and ex ovo. Blood biocompatibility of dHCM was also shown by studying plasma protein adsorption, platelet adhesion and activation, and its hemolytic potential. Furthermore, dHCM antibacterial properties against Staphylococcus aureus were also studied. In summary, the dHCM reticular layer side presented all the needed characteristics to be used in the inner side of a vascular graft. Additionally, the mechanica...Continue Reading

References

Mar 23, 2001·Journal of Biomaterials Applications·H J SalacinskiR J Carson
Dec 4, 2004·Methods in Molecular Biology·Chris StorgardDwayne G Stupack
Apr 5, 2007·Nature Protocols·Domenico RibattiMarco Presta
Apr 9, 2008·Current Topics in Medicinal Chemistry·Paul ThevenotLiping Tang
Jul 8, 2008·The Journal of Thoracic and Cardiovascular Surgery·Kei TorikaiYoshiki Sawa
Feb 19, 2009·Molecular and Cellular Biology·Hai Tao YuanSamir M Parikh
Dec 1, 2009·Biomaterials·Li Buay KohSubbu S Venkatraman
Dec 19, 2009·Regenerative Medicine·Swathi Ravi, Elliot L Chaikof
May 15, 2010·Acta Biomaterialia·Benedetto MarelliMaria Cristina Tanzi
May 24, 2012·Tissue Engineering. Part C, Methods·Salma Amensag, Peter S McFetridge
May 26, 2012·Trends in Cardiovascular Medicine·Shannon L M DahlLaura E Niklason
Jul 25, 2012·Journal of Biomedical Materials Research. Part a·Maritza RodriguezPeter S McFetridge
Oct 13, 2012·Macromolecular Bioscience·Benedetto MarelliDiego Mantovani
Sep 1, 2011·Cardiovascular Engineering and Technology·Vivek A KumarElliot L Chaikof
Feb 14, 2013·The International Journal of Artificial Organs·Irene CattaneoAndrea Remuzzi
May 15, 2013·Journal of Biomedical Materials Research. Part a·Salma Amensag, Peter S McFetridge
Aug 27, 2013·Acta Biomaterialia·Anwarul HasanAli Khademhosseini
Jul 22, 2014·Journal of Biomedical Materials Research. Part a·Nuno AlexandreAna Lúcia Luís
Sep 17, 2014·Journal of Visualized Experiments : JoVE·Katie L DeCicco-SkinnerJonathan S Wiest
Sep 19, 2014·Antimicrobial Resistance and Infection Control·Ethan E MannShravanthi T Reddy
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Li-Chong XuChristopher A Siedlecki
Jun 6, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Valentina CattoMaria Cristina Tanzi
Jul 8, 2015·Journal of Thrombosis and Haemostasis : JTH·I H JafferJ I Weitz
Oct 4, 2015·Acta Biomaterialia·Karl Heinrich SchneiderAndreas Herbert Teuschl
May 15, 2016·Mechanisms of Development·Domenico Ribatti
Apr 12, 2017·Journal of Materials Science. Materials in Medicine·Chiara MarcolinSilvia Faré
Jan 9, 2020·Journal of Biomaterials Applications·Sonal WalawalkarShahdab Almelkar
Apr 27, 2020·Methods in Cell Biology·Laura P FrazãoNuno M Neves
Aug 20, 2020·Cardiovascular Engineering and Technology·Francis O ObiweluozorIn Seok Jeong
Dec 17, 2020·Bioengineering·Panagiotis MallisEfstathios Michalopoulos
Feb 9, 2021·Advanced Functional Materials·Bita NasiriStelios T Andreadis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.