New WHO classification of lung adenocarcinoma and preneoplasia

Annales de pathologie
Sylvie LantuejoulWilliam D Travis

Abstract

The 2015 WHO classification of tumors of the lung, pleura, thymus and heart has just been published with numerous important changes from the 2004 WHO classification. The most significant changes involve (1) use of immunohistochemistry throughout the classification, (2) integration of molecular testing for personalized strategies for advanced lung cancer patients, (3) a new classification for small biopsies and cytology, (4) a new classification of lung adenocarcinoma as proposed by the 2011 IASLC/ATS/ERS, (5) restriction of the diagnosis of large cell carcinoma only to resected tumors that lack any clear morphologic or immunohistochemical differentiation. Regarding adenocarcinoma, the terms bronchioloalveolar carcinoma (BAC) and mixed subtype adenocarcinoma have been suppressed and replaced for the former by the term adenocarcinoma in situ (AIS) as a preinvasive lesion to join atypical adenomatous hyperplasia (AAH). A new category has been defined, the minimally invasive adenocarcinoma (MIA), and invasive adenocarcinomas are now classified according to the predominant subtype after subtyping by semi-quantitatively percentage of various subtypes present in 5% increments. The term "lepidic" is restricted to a non-invasive compone...Continue Reading

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Citations

Feb 7, 2020·JCO Clinical Cancer Informatics·James L MulshineJohn K Field
Jan 6, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul A Bunn
Jan 9, 2019·Frontiers in Oncology·Liyuan JiaJihong Cui
Feb 18, 2020·Proceedings·Ajay TambeRana Naous
Aug 9, 2019·Journal of Translational Medicine·Shirong ZhangShenglin Ma

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