PMID: 11917738Mar 29, 2002Paper

Newborn intestinal circulation. Physiology and pathophysiology

Clinics in Perinatology
Kristina M ReberPhilip T Nowicki

Abstract

The physiologic characteristics of the newborn intestinal circulation are unique when compared with the adult condition. Most important, intestinal vascular resistance across newborn intestine is exceptionally low and this transient reduction is mediated by an increased constitutive and stimulated production of NO. The low vascular resistance characteristic of newborn intestine alters the capacity of this vasculature to respond to systemic circulatory perturbations, such as hypotension and arterial hypoxemia. The essential role of endothelial production of NO in maintaining newborn intestinal hemodynamics might be important in the pathogenesis of NEC, because endothelial dysfunction would limit, or possibly eliminate, NO production, leading to substantial intestinal ischemia.

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Citations

Jun 1, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Rob M Moonen, Eduardo Villamor
Jun 10, 2010·Pediatric Surgery International·Carmen TurowskiJohn Gillick
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Mar 22, 2006·Pediatric Research·Philip T NowickiDonna A Caniano
Jun 29, 2007·Pediatric Research·Rob M J MoonenEduardo Villamor
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