Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils

Veterinary Immunology and Immunopathology
K M LamJ P Eiserich

Abstract

The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H2O2 production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.

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Citations

Oct 1, 1996·Journal of Comparative Pathology·K M Lam
Mar 16, 2000·Developmental and Comparative Immunology·B S SealH S Sellers
Jul 1, 1997·Veterinary Immunology and Immunopathology·K M Lam
Jul 10, 1998·Veterinary Immunology and Immunopathology·N C RathW E Huff
Oct 25, 2002·Avian Pathology : Journal of the W.V.P.A·K M Lam, R J Munn
Nov 26, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yaling LiTao Ren
Nov 16, 2007·International Journal of Immunogenetics·K A AhmedT J Rasool
Dec 24, 2010·The Journal of General Virology·Cary A RueClaudio L Afonso
Apr 30, 2013·Developmental and Comparative Immunology·Darrell R KapczynskiPatti J Miller
Jan 17, 2019·Oxidative Medicine and Cellular Longevity·Zaib Ur RehmanChan Ding

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis