Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe

Experimental Cell Research
J AlmkvistAnna Karlsson

Abstract

Human neutrophils are activated by the beta-galactoside-binding lectin galectin-3, provided that the cells are primed by in vivo extravasation or by in vitro preactivation with, for example, LPS. Removal of terminal sialic acid can change neutrophil functionality and responsiveness due to exposure of underlying glycoconjugate receptors or change in surface charge. Here, we investigated whether such alteration of the cell surface carbohydrate composition can alter the responsiveness of the cells to galectin-3. Neutrophils were treated with neuraminidases (NA) of different origins: Clostridium perfringens (CP), Salmonella typhimurium, Vibrio cholerae, and Newcastle disease virus (NDV). In the presence of NDV-NA, but no other NA, the otherwise non-responding neutrophils responded readily to galectin-3 by activation of the NADPH-oxidase. The galectin-3 priming effect was inhibited by the sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetyl-neuraminic acid. Earlier studies have shown that priming of the neutrophil response to galectin-3 with, for example, LPS is paralleled by degranulation of intracellular vesicles and granules and upregulation of potential galectin-3 receptors. Also, NDV-NA (but not CP-NA) treatment induced degranulati...Continue Reading

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Citations

May 16, 2009·Nature Reviews. Microbiology·Gerardo R Vasta
Oct 28, 2011·PloS One·Marise Lopes FerminoLise Halbwachs-Mecarelli
Jun 15, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Fabiana H M de MeloRoger Chammas
Nov 2, 2005·Journal of Leukocyte Biology·Julie NieminenSachiko Sato
Aug 20, 2019·Animal Biotechnology·Sarah Adjei-Fremah, Mulumebet Worku
Aug 24, 2019·Frontiers in Immunology·Brian S RobinsonSean R Stowell
Mar 20, 2012·PLoS Neglected Tropical Diseases·Joanna WaldockGeorge K Christophides

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