Newer antidepressants for hot flashes--should their efficacy still be up for debate?

Menopause : the Journal of the North American Menopause Society
C L LoprinziSherry L Wolf

Abstract

Newer antidepressants have been shown in clinical trials to reduce hot flashes, although not as well as do hormones. Nonetheless, a recently published meta-analysis and subsequent editorial raised doubts with regard to the utility of newer antidepressants for treating hot flashes. Concerns about the lack of efficacy of newer antidepressants on hot flashes were based in large part on results of two placebo-controlled, double-blind trials, one evaluating venlafaxine and the other individually evaluating both fluoxetine and citalopram. These two studies have repeatedly been put forward as evidence that newer antidepressants are not definitively proven to reduce hot flashes. Raw data from these two randomized, placebo-controlled trials evaluating second-generation antidepressants for hot flashes were obtained. These data and subsequent study conclusions are evaluated and discussed in the context of other published trial data regarding the use of newer antidepressants for treating hot flashes. Examination of the raw data from these two trials revealed that neither employed a baseline period of hot flash determination against which to calculate changes over time from baseline. Recognition that these two trials cannot be used to look ...Continue Reading

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Citations

Feb 4, 2009·Menopause : the Journal of the North American Menopause Society·Aditya BardiaCharles Loprinzi
Sep 9, 2011·Menopause : the Journal of the North American Menopause Society·Sandhya PruthiDebra L Barton
Apr 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L LoprinziPaul Novotny
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Debra L BartonCharles L Loprinzi
Aug 27, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Wenjuan WangWenpei Bai
Sep 14, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L LoprinziRui Qin
Mar 11, 2020·Chronobiology International·Qunyan XuJane Warland
Sep 9, 2010·The Cochrane Database of Systematic Reviews·Gabriel RadaClaudio Vera

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