Abstract
Myocarditis is thought to be commonly caused by various viruses, and accumulating evidence links viral myocarditis with the eventual development of dilated cardiomyopathy. In many cases, however, the evidence is only circumstantial, and direct conclusive proof is not available. Polymerase chain reaction (PCR) has been used to detect enterovirus RNA in myocardial tissue, but the wide discrepancy in results emphasizes the need for further study. We evaluated patients with cardiomyopathy and myocarditis by PCR for the presence of various RNA and DNA viruses in the heart. Hepatitis C virus RNA was found in high frequency, but enterovirus RNA was detected only in low frequency. Therefore, we investigated hepatitis C virus infection in patients with dilated cardiomyopathy. Antihepatitis C virus antibody was present in the sera of 6 of 36 patients (16.7%) with dilated cardiomyopathy and in 1 of 40 patients (2.5%) with ischemic heart disease, showing a statistically significant (P < .05) difference. Hepatitis C virus RNA was present in the sera of four of the six patients, and all four had hepatitis C virus type II. The copy number of hepatitis C virus RNA in the serum was 8 x 10(2) to 2 x 10(3) genomes per 1 mL serum. Positive strands...Continue Reading
References
Dec 31, 1992·The New England Journal of Medicine·M J AlterR E Sampliner
Aug 1, 1992·Circulation·B KyuS Tracy
Nov 1, 1991·The American Journal of Medicine·T A KnoxE M Berkman
Jul 1, 1990·Circulation·O JinC C Liew
Apr 21, 1989·Science·Q L ChooM Houghton
May 1, 1989·Journal of the American College of Cardiology·W H Abelmann, B H Lorell
Sep 15, 1989·Annals of Internal Medicine·M Lisker-MelmanJ H Hoofnagle
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R KandolfP H Hofschneider
Oct 1, 1987·The American Journal of Medicine·L BonomoD Caccavo
May 1, 1980·The American Journal of Cardiology·J W MasonD R Ricci
Nov 1, 1995·Circulation·A MatsumoriS Sasayama
Jul 1, 1994·Circulation·A B MartinJ Ni
Jun 1, 1994·Circulation·H J WhyL C Archard
May 1, 1993·The Journal of Clinical Investigation·K T Nouri AriaR Williams
Citations
Jul 21, 2004·International Journal of Cardiology·Willam KcomtDavid Stein
Jun 27, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·K M MeursJ A Towbin
Mar 2, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alessandro AntonelliPoupak Fallahi
May 21, 1999·Journal of Medical Virology·D PratiG Sirchia
Dec 17, 2009·Journal of Viral Hepatitis·A AntonelliP Fallahi
Apr 14, 2015·World Journal of Hepatology·Ioana Mozos
Jan 1, 2016·Terapevticheskiĭ arkhiv·L A StrizhakovM V Taranova
Jan 15, 1999·The Journal of Cardiovascular Nursing·P S Sparacino