Newfound sex differences in axonal structure underlie differential outcomes from in vitro traumatic axonal injury

Experimental Neurology
Jean-Pierre DolléDouglas H Smith

Abstract

Since traumatic axonal injury (TAI) is implicated as a prominent pathology of concussion, we examined potential sex differences in axon structure and responses to TAI. Rat and human neurons were used to develop micropatterned axon tracts in vitro that were genetically either male or female. Ultrastructural analysis revealed for the first time that female axons were consistently smaller with fewer microtubules than male axons. Computational modeling of TAI showed that these structural differences place microtubules in female axons at greater risk of failure during trauma under the same applied loads than in male axons. Likewise, in an in vitro model of TAI, dynamic stretch-injury to axon tracts induced greater pathophysiology of female axons than male axons, including more extensive undulation formations resulting from mechanical breaking of microtubules, and greater calcium influx shortly after the same level of injury. At 24h post-injury, female axons exhibited significantly more swellings and greater loss of calcium signaling function than male axons. Accordingly, sexual dimorphism of axon structure in the brain may also contribute to more extensive axonal pathology in females compared to males exposed to the same mechanical ...Continue Reading

References

Dec 11, 1992·Brain Research·F AboitizE Zaidel
Apr 1, 1991·The Journal of Cell Biology·P A JanmeyM Schliwa
Feb 1, 1980·Archives of Neurology·H A SwadlowN Geschwind
Jul 1, 1996·Journal of Neuropathology and Experimental Neurology·K E SaatmanT K McIntosh
Jun 22, 1999·Journal of Neuropathology and Experimental Neurology·X H ChenD H Smith
Aug 3, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·J J Bazarian, S Atabaki
May 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akira IwataDouglas H Smith
Jun 2, 2005·Journal of Neurosurgery·Donna K BroshekJeffrey T Barth
Jun 2, 2007·Acta Biomaterialia·Subra Suresh
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Samuel S-H WangKrysta D Wyatt
Sep 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer S PerrinTomás Paus
Jul 1, 2009·Journal of Neuroscience Research·Tracy J YuenDouglas H Smith
Sep 16, 2009·Frontiers in Neuroanatomy·Tomás Paus, Roberto Toro
Dec 19, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Min D Tang-SchomerDouglas H Smith
Jun 29, 2010·NeuroImage·Daniel C AlexanderTim B Dyrby
Jan 18, 2011·Journal of Neurotrauma·Jerome A Staal, James C Vickers
Apr 19, 2011·The Journal of Biological Chemistry·Susanne WegmannDaniel J Muller
Jul 30, 2011·Journal of Neurogenetics·Erika PedrosaHerbert M Lachman
Jan 31, 2012·Experimental Neurology·Victoria E JohnsonDouglas H Smith
Jan 31, 2012·The American Journal of Sports Medicine·Mallika MararR Dawn Comstock
Feb 10, 2012·Journal of Neuropathology and Experimental Neurology·Thomas M ReevesLinda L Phillips
Dec 12, 2012·Annals of Neurology·Esther L YuhUNKNOWN TRACK-TBI Investigators
Mar 6, 2013·Nature Reviews. Neurology·Douglas H SmithWilliam Stewart
Sep 21, 2013·British Journal of Sports Medicine·Shameemah AbrahamsAlison V September
Aug 28, 2014·PloS One·Austin SendekDaniel L Cox
Dec 5, 2015·Biophysical Journal·Hossein AhmadzadehVivek B Shenoy
Jan 20, 2016·BMC Emergency Medicine·Christopher E Gaw, Mark R Zonfrillo
Aug 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Wen LuVladimir I Gelfand
Apr 5, 2017·Cold Spring Harbor Perspectives in Biology·Aidong YuanRalph A Nixon

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Citations

Jan 9, 2019·The Clinical Neuropsychologist·Victoria C MerrittAmy J Jak
Apr 4, 2019·The American Journal of Sports Medicine·Margot PutukianDouglas J Wiebe
Feb 23, 2019·Journal of Neurotrauma·Raeesa GupteJanna Harris
May 24, 2019·Journal of Neurotrauma·Elisabeth A WildeHarvey Levin
Jan 25, 2020·Clinical Pediatrics·Kristen KolbergAndrew Hashikawa
Jun 2, 2020·Human Brain Mapping·Emily L DennisElisabeth A Wilde
Jul 17, 2020·Seminars in Neurology·Alyssa PhelpsMichael L Alosco
Dec 1, 2020·Frontiers in Neuroscience·Nicole A PelotWarren M Grill
Dec 17, 2020·Frontiers in Neurology·Ann N HoffmanMichael S Fanselow
Dec 29, 2020·The Journal of Head Trauma Rehabilitation·Eve M ValeraPatrick S F Bellgowan
May 6, 2019·Experimental Neurology·Naomi S Sta MariaChristopher C Giza
Apr 28, 2021·JAMA Network Open·Abigail C BretzinWilliam Stewart
Nov 15, 2020·Clinics in Sports Medicine·Katherine H Rizzone, Kathryn E Ackerman
Aug 5, 2021·Nature·Katharine Sanderson
Jul 3, 2021·Journal of Neurotrauma·Douglas H SmithFiona Crawford
May 17, 2021·Journal of Science and Medicine in Sport·Haley M ChizukJohn J Leddy

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