Newly described translocation (18;19)(q23;q13.2) in abdominal wall soft-tissue tumor resembling Ewing sarcoma/primitive neuroectodermal tumor

Cancer Genetics and Cytogenetics
Gina F RiccardiTimothy A Damron

Abstract

From a morphologic standpoint, Ewing sarcoma (EWS) is one of a number of pediatric malignancies that are characterized by sheets of small, round, blue cells. Ewing sarcoma can usually be differentiated from other small round blue cell tumors by the presence of a gene rearrangement having a consistent breakpoint within the Ewing sarcoma gene (EWSR1) at 22q12. Although the most common translocation partner is FLI1, located at 11q24, there is a growing list of alternate rearrangements involving different loci. We describe the first example of a soft-tissue sarcoma morphologically and immunohistochemically similar to Ewing sarcoma, but with a novel t(18;19)(q23;q13.2).

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Citations

Nov 21, 2014·Head and Neck Pathology·Brian D StewartAngela C Chi
Feb 4, 2014·Archives of Medical Research·M Verónica Ponce-CastañedaM de Lourdes Cabrera-Muñoz
May 8, 2014·The International Journal of Biochemistry & Cell Biology·Adrián Mariño-Enríquez, Christopher D M Fletcher
Feb 18, 2015·BioMed Research International·Roumiana Todorova
Oct 12, 2000·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·J J Perry, L D Higgins
Aug 12, 2014·Advances in Anatomic Pathology·Shi Wei, Gene P Siegal
Jun 10, 2011·Current Opinion in Oncology

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