PMID: 18187850Jan 12, 2008Paper

Newly developed chemical probes and nano-devices for cellular analysis

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Aki HondaKoji Suzuki

Abstract

A cellular analyzing system including a "real-time cellular imaging system" and a "comprehensive analyzing system for cellular responses" was developed. A "real-time cellular imaging system" is a system used to measure real-time imaging of multiple phenomena of a single cell with high special and temporal resolutions for the purpose to understand the pathology and physiology in a single cell and realize to single cell level diagnosis. A "real-time cellular imaging system" includes multi-probe imaging with AFM (atomic force microscopy), optical and SECM (scanning electrochemical microscopy) modes, which provides us with topological information and biochemical reactions at the local area of the interior and exterior of a cell. Scanning electrochemical/optical microscopy was applied to image PC12 cells. On the other hand, cells respond to their specific substances via their ligands. Therefore, the comprehensive analysis of protein-protein interaction is the important issue to determine the functions of cells. For this purpose, a "comprehensive analysis system for cellular responses" was developed. This system is based on SPR (surface plasmon resonance) and MS (mass spectrometry) using a nano-fabricated substrate. The interaction b...Continue Reading

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Citations

Mar 10, 2010·Annals of Biomedical Engineering·Yoon-Kyoung ChoTaesung Kim
Jun 11, 2011·Biomarkers in Medicine·Paulina D Rakowska, Maxim G Ryadnov
Nov 1, 2008·Expert Opinion on Drug Discovery·Kristin SottMattias Goksör
Aug 18, 2010·Organic & Biomolecular Chemistry·Fumihiro ItoKentaro Yamaguchi
Mar 15, 2011·Organic & Biomolecular Chemistry·Fumihiro Ito, Kentaro Yamaguchi

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