Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome.

Lancet
Thijs KuikenAlbert D M E Osterhaus

Abstract

The worldwide outbreak of severe acute respiratory syndrome (SARS) is associated with a newly discovered coronavirus, SARS-associated coronavirus (SARS-CoV). We did clinical and experimental studies to assess the role of this virus in the cause of SARS. We tested clinical and postmortem samples from 436 SARS patients in six countries for infection with SARS-CoV, human metapneumovirus, and other respiratory pathogens. We infected four cynomolgus macaques (Macaca fascicularis) with SARS-CoV in an attempt to replicate SARS and did necropsies on day 6 after infection. SARS-CoV infection was diagnosed in 329 (75%) of 436 patients fitting the case definition of SARS; human metapneumovirus was diagnosed in 41 (12%) of 335, and other respiratory pathogens were diagnosed only sporadically. SARS-CoV was, therefore, the most likely causal agent of SARS. The four SARS-CoV-infected macaques excreted SARS-CoV from nose, mouth, and pharynx from 2 days after infection. Three of four macaques developed diffuse alveolar damage, similar to that in SARS patients, and characterised by epithelial necrosis, serosanguineous exudate, formation of hyaline membranes, type 2 pneumocyte hyperplasia, and the presence of syncytia. SARS-CoV was detected in pn...Continue Reading

References

Jan 1, 1977·Archives of Virology·P N Bhatt, R O Jacoby
May 30, 1992·The Veterinary Record·Y ElazharyB G Talbot
Dec 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H C ClaasW G Quint
Jan 23, 1988·The Veterinary Record·D J GarwesI Brown
May 23, 2002·The Journal of Infectious Diseases·Teresa C T PeretLarry J Anderson
Nov 1, 2002·Medical Microbiology and Immunology·Sibylle Schneider-SchauliesVolker Ter Meulen
Apr 3, 2003·The New England Journal of Medicine·Susan M PoutanenUNKNOWN Canadian Severe Acute Respiratory Syndrome Study Team
Apr 3, 2003·The New England Journal of Medicine·Kenneth W TsangKar N Lai
Apr 16, 2003·The New England Journal of Medicine·Nelson LeeJoseph J Y Sung
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
Apr 25, 2003·Lancet·J S M PeirisUNKNOWN SARS study group
May 16, 2003·Nature·Ron A M FouchierAlbert D M E Osterhaus
Jun 5, 2003·Emerging Infectious Diseases·J S Malik PeirisSusan S Chiu
Jun 5, 2003·Lancet·John M NichollsJ S Malik Peiris
Oct 2, 2003·Emerging Infectious Diseases·Paul K S ChanJoseph J Y Sung
Oct 25, 2003·Avian Diseases·R A M FouchierA D M E Osterhaus
Oct 31, 2003·Thorax·N L Müller, J M FitzGerald

❮ Previous
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Citations

Nov 27, 2004·Reviews in Medical Virology·UNKNOWN SARS Investigation Team from DMERI, UNKNOWN SGH
Aug 8, 2007·Journal of Structural and Functional Genomics·Mark BartlamZihe Rao
Apr 10, 2008·Journal of Biomedical Science·Hsin-Chieh MaShih-Yen Lo
May 3, 2011·Protein & Cell·Bin Xia, Xue Kang
Apr 3, 2004·American Journal of Ophthalmology·Kenneth S C YuenDennis S C Lam
Jan 31, 2004·Biochemical and Biophysical Research Communications·Mau-Sun ChangYuh-Cheng Yang
Mar 9, 2005·Biochemical and Biophysical Research Communications·Els KeyaertsMarc Van Ranst
Mar 16, 2005·Biochemical and Biophysical Research Communications·Emi HamanoNaoto Keicho
Jun 14, 2005·Current Opinion in Immunology·Yu Lung Lau, J S Malik Peiris
Dec 10, 2003·Current Opinion in Biotechnology·Thijs KuikenAlbert Osterhaus
Oct 3, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Leo L M PoonJoseph S M Peiris
Oct 3, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·J S M Peiris
Dec 17, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·A BergerW Preiser
May 12, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Martin SpiegelFriedemann Weber
Aug 10, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Matthias NiedrigMaria Zambon
Apr 7, 2004·The Journal of Infection·Ai Ping Chua, Kang Hoe Lee
Mar 17, 2004·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Michael J StanhopeHeather Amrine-Madsen
Jul 28, 2006·Epidemiology and Infection·P A TuanUNKNOWN WHO SARS Investigation Team in Vietnam
Apr 28, 2010·Biochemistry·Jennifer BarrilaErnesto Freire
Apr 24, 2012·Chemical Reviews·Reem SmoumMorris Srebnik
Jul 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David M HwangJagdish Butany
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wai S ChanAnthony W I Lo
Dec 4, 2004·Nature Medicine·J S M PeirisK Y Yuen
Dec 3, 2005·Nature Reviews. Immunology·Stanley Perlman, Ajai A Dandekar
Feb 10, 2009·Nature Reviews. Microbiology·Lanying DuShibo Jiang
Mar 24, 2004·Nature Reviews. Microbiology·Konrad StadlerRino Rappuoli
Jun 16, 2004·Nature Reviews. Microbiology·B Brett FinlayRobert C Brunham
Sep 17, 2004·Nature Reviews. Microbiology·Erik De Clercq
Oct 18, 2005·Nature Structural & Molecular Biology·Yujia ZhaiZihe Rao
Mar 17, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·John NichollsMalik Peiris
Dec 19, 2003·The New England Journal of Medicine·Joseph S M PeirisKlaus Stöhr
Nov 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Karl W BoehmeTerence S Dermody
Sep 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Emmie de WitVincent J Munster
Nov 17, 2005·Journal of Neurovirology·Samson S Y Wong, K Y Yuen
Oct 10, 2007·The Journal of Experimental Medicine·Yongxiong ChenChen-Lung Steve Lin
Dec 31, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L L M PoonJ S M Peiris
Feb 7, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·V C C ChengK Y Yuen
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael D ChristianDonald E Low
Jan 31, 2012·Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science·J Glenn MorrisJames M Hughes
Mar 8, 2008·ILAR Journal·Murray B Gardner, Paul A Luciw

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Methods Mentioned

BETA
transmission
biopsy
bronchoalveolar
lavage
transmission electron microscopy
enzyme-linked immunosorbent assay
PCR
electron microscopy
nucleic acid isolation

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