Newly identified loci that influence lipid concentrations and risk of coronary artery disease

Nature Genetics
Cristen J WillerGonçalo R Abecasis

Abstract

To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising 6,068 individuals specific to our study (1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables) and 2,758 individuals from the Diabetes Genetics Initiative, reported in a companion study in this issue. We subsequently examined promising signals in 11,569 additional individuals. Overall, we identify strongly associated variants in eleven loci previously implicated in lipid metabolism (ABCA1, the APOA5-APOA4-APOC3-APOA1 and APOE-APOC clusters, APOB, CETP, GCKR, LDLR, LPL, LIPC, LIPG and PCSK9) and also in several newly identified loci (near MVK-MMAB and GALNT2, with variants primarily associated with high-density lipoprotein (HDL) cholesterol; near SORT1, with variants primarily associated with low-density lipoprotein (LDL) cholesterol; near TRIB1, MLXIPL and ANGPTL3, with variants primarily associated with triglycerides; and a locus encompassing several genes near NCAN, with variants strongly associated with both triglycerides and LDL cholesterol). Notab...Continue Reading

References

Mar 20, 1999·The Journal of Biological Chemistry·M S NielsenC M Petersen
Jan 13, 2000·American Journal of Human Genetics·G R AbecasisW O Cookson
Apr 21, 2001·Biometrics·B Devlin, K Roeder
Jan 5, 2002·Cellular and Molecular Life Sciences : CMLS·U RauchX H Zhou
Jan 15, 2002·Nature Genetics·Ryuta KoishiHidehiko Furukawa
Oct 16, 2003·JAMA : the Journal of the American Medical Association·Nir BarzilaiAlan R Shuldiner
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Mar 5, 2004·Journal of the American College of Cardiology·Antonio M Gotto, Eliot A Brinton
Apr 30, 2004·European Journal of Clinical Nutrition·P C ElwoodA R Ness
Jun 5, 2004·Atherosclerosis·Toni I PollinBraxton D Mitchell
Jul 17, 2004·International Journal of Epidemiology·Bernard KeavneyUNKNOWN International Studies of Infarct Survival (ISIS) Collaborators
Aug 7, 2004·Science·Jonathan C CohenHelen H Hobbs
Aug 10, 2004·The Journal of Biological Chemistry·Endre Kiss-TothSteven K Dower
Oct 15, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Rossi P NaoumovaAnne K Soutar
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Aug 22, 2006·Nature Genetics·Joshua T BurdickVivian G Cheung
Aug 29, 2006·PLoS Genetics·Giuseppe PiliaDavid Schlessinger
Jan 31, 2007·Circulation·Wendy PostBraxton D Mitchell
Feb 16, 2007·Biochemical and Biophysical Research Communications·Charlotte MurphyMats Gåfvels
Apr 28, 2007·Science·UNKNOWN Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical RShaun Purcell
May 5, 2007·Science·Anna HelgadottirKari Stefansson
May 5, 2007·Science·Ruth McPhersonJonathan C Cohen
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Jul 11, 2007·Archives of Internal Medicine·Robert ClarkeRory Collins
Jul 20, 2007·The New England Journal of Medicine·Nilesh J SamaniUNKNOWN WTCCC and the Cardiogenics Consortium
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Børge G NordestgaardAnne Tybjaerg-Hansen
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Sandeep BansalPaul M Ridker
Oct 10, 2007·American Journal of Human Genetics·Wei-Min Chen, Goncalo R Abecasis
Jul 26, 2008·Nature Nanotechnology

❮ Previous
Next ❯

Citations

Jan 30, 2009·JAMA : the Journal of the American Medical Association·Jun J YangMary V Relling
Jul 2, 2009·JAMA : the Journal of the American Medical Association·Paul ElliottJaspal S Kooner
Feb 18, 2010·JAMA : the Journal of the American Medical Association·Nina P PaynterPaul M Ridker
Jul 24, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nilesh J SamaniMartin D Tobin
Jun 26, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Julia PerttiläVesa M Olkkonen
Aug 8, 2009·Diabetologia·J R B PerryT M Frayling
Aug 10, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Constantin RoderBoris Krischek
Mar 21, 2009·Human Genetics·Himadri RoySeppo Yla-Herttuala
Jun 11, 2009·Human Genetics·Kunihiko HinoharaAkinori Kimura
Apr 7, 2010·Human Genetics·Kazuhiro NakayamaUNKNOWN Jichi Medical University Promotion Team of a Large-scale Human Genome Bank for All over Japan
Apr 17, 2008·Journal of Inherited Metabolic Disease·M KlugerM Merkel
Nov 6, 2009·European Journal of Epidemiology·Gabriella AndreottiAnn W Hsing
Aug 13, 2008·Glycoconjugate Journal·E Tian, Kelly G Ten Hagen
Jun 1, 2012·Glycoconjugate Journal·Vlatka ZoldošGordan Lauc
Aug 9, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Ke ZhuangLongxian Cheng
Apr 28, 2012·Current Atherosclerosis Reports·Alanna Strong, Daniel J Rader
Dec 13, 2012·Current Atherosclerosis Reports·Daniel Steinberg
Feb 3, 2012·Current Diabetes Reports·Susann BlüherPeter E H Schwarz
Oct 23, 2009·Journal of Molecular Neuroscience : MN·Luca JáromiBéla Melegh
Feb 28, 2009·The Proceedings of the Nutrition Society·Gerald Rimbach, Anne M Minihane
Oct 4, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Ida SurakkaUNKNOWN GenomEUtwin Project
Oct 22, 2009·European Journal of Human Genetics : EJHG·Tuuli LappalainenJuha Kere
Nov 26, 2009·European Journal of Human Genetics : EJHG·Tiia Kangas-KontioMarkku J Savolainen
Jun 24, 2010·European Journal of Human Genetics : EJHG·Chao Qiang JiangG Neil Thomas
Jun 24, 2010·European Journal of Human Genetics : EJHG·Alice Marques-PinheiroMathilde Varret
Aug 19, 2011·European Journal of Human Genetics : EJHG·Jessica BeckerJohannes Schumacher
Mar 31, 2011·European Journal of Human Genetics : EJHG·Ayşe DemirkanUNKNOWN ENGAGE CONSORTIUM
May 31, 2012·European Journal of Human Genetics : EJHG·Binod NeupaneJoseph Beyene
Sep 23, 2011·Journal of Human Genetics·Kazuhiro NakayamaSadahiko Iwamoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Related Papers

The New England Journal of Medicine
N J SamaniWTCCC and the Cardiogenics Consortium
Science
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical RShaun Purcell
© 2021 Meta ULC. All rights reserved