Newly recognized GnRH receptors: function and relative role

Trends in Endocrinology and Metabolism : TEM
Jimmy D NeillL W Duck

Abstract

Hypothalamic gonadotropin releasing hormone (GnRH I) and its pituitary receptor are responsible for the CNS regulation of reproduction. However, a second GnRH (GnRH II) is also expressed in humans and a gene that resembles the GnRH II receptor in fish has been identified in humans and monkeys. The amino-acid sequence of this newly identified, seven-transmembrane, G-protein-coupled receptor in monkeys differs from the human GnRH I receptor by having a C-terminal, cytoplasmic tail. GnRH II is approximately 400-fold more potent at GnRH II receptors than GnRH I receptors. GnRH I directly inhibits proliferation of human tumor cells, and GnRH II and its receptor might have a similar role. Limited progress has been made, however, because of difficulty translating the mRNA that encodes the human GnRH II receptor. Nevertheless, such receptors are likely to exist in humans because GnRH II is more inhibitory to tumor cell replication than GnRH I, and GnRH I and GnRH II have reciprocal effects on human decidual stromal cells in culture. The focus of this review is the identity of a possible translatable, functional GnRH II receptor in humans. The two possibilities considered are either that GnRH II receptor mRNA is expressed that encodes e...Continue Reading

References

Nov 30, 1992·Biochemical and Biophysical Research Communications·S S KakarJ D Neill
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Kozak
Dec 1, 1981·Pharmacology, Biochemistry, and Behavior·J E ZadinaD H Coy
Jul 28, 1995·The Journal of Biological Chemistry·T SchönebergJ Wess
Jan 1, 1995·Cytogenetics and Cell Genetics·S S Kakar, J D Neill
Jan 15, 1997·European Journal of Biochemistry·C TensenH Goos
Jan 1, 1997·Annual Review of Neuroscience·T GudermannG Schultz
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·R B WhiteR D Fernald
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·G EmonsK D Schulz
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·K LingG Pei
Dec 22, 1999·Trends in Cell Biology·J AdamsL Cooley
Jun 1, 2000·European Journal of Endocrinology·G EmonsK D Schulz
May 16, 2001·Biochemical and Biophysical Research Communications·J D NeillL C Musgrove
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·R MillarA Katz
Nov 10, 2001·Annual Review of Genomics and Human Genetics·P Mombaerts
Dec 14, 2001·Biochemical and Biophysical Research Communications·M EnomotoM K Park
Jan 29, 2002·Nucleic Acids Research·M Kozak
Feb 28, 2002·Endocrinology·Jimmy D Neill
Apr 6, 2002·Archives of Physiology and Biochemistry·J D Neill
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Xiaohui TangYuji Taketani
Nov 22, 2002·Biology of Reproduction·W van BiljonJ Hapgood
Dec 12, 2002·Trends in Endocrinology and Metabolism : TEM·Robert P Millar
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Valerie S Densmore, Henryk F Urbanski
May 29, 2003·Molecular and Cellular Endocrinology·Peter C K LeungXiao-Ming Zhu
Jun 7, 2003·Endocrine-related Cancer·G EmonsC Verschraegen
Oct 25, 2003·Endocrinology·Alexander S Kauffman, Emilie F Rissman
Nov 5, 2003·Reproductive Biology and Endocrinology : RB&E·Carsten Gründker, Günter Emons

❮ Previous
Next ❯

Citations

Sep 29, 2005·European Journal of Endocrinology·Nicola EickeCarsten Gründker
Aug 12, 2014·General and Comparative Endocrinology·Graeme J RochNancy M Sherwood
Aug 4, 2007·Journal of Molecular Histology·Chenyu ChuWeiquan Huang
Jan 12, 2010·Cellular and Molecular Life Sciences : CMLS·Jose Córdoba-ChacónJusto P Castaño
Aug 1, 2012·Drug Delivery and Translational Research·Priti TomarV K Dixit
Apr 1, 2005·Fish Physiology and Biochemistry·Ishwar S Parhar
Apr 7, 2012·European Journal of Medicinal Chemistry·Ulrike LeursMarilena Manea
Dec 31, 2015·Human Reproduction Update·Roberto MaggiPatrizia Limonta
Sep 10, 2005·Reproduction in Domestic Animals = Zuchthygiene·J KauffoldK-P Brüssow
Sep 15, 2005·Journal of Neuroendocrinology·J P HapgoodK Ronacher
Mar 11, 2011·Annals of the New York Academy of Sciences·José Córdoba-ChacónJusto P Castaño
May 3, 2006·Theriogenology·Falk SchneiderCarsten Gründker
Mar 21, 2006·Cancer Letters·Sarah KrausRony Seger
Sep 24, 2005·Endocrinology·Deborah K BarnettDavid H Abbott
Jul 11, 2012·Endocrine Reviews·Patrizia LimontaRoberta M Moretti
Oct 4, 2012·American Journal of Physiology. Endocrinology and Metabolism·Mario Durán-PradoJusto P Castaño
Sep 19, 2020·Molecular Cancer Therapeutics·Mark Seungwook KimAnil K Sood
Oct 30, 2020·International Journal of Molecular Sciences·Lorraine PeaceyChristopher E Jones
Dec 18, 2020·International Journal of Molecular Sciences·Fabrizio FontanaPatrizia Limonta
Mar 7, 2021·Cells·Carsten Gründker, Günter Emons
Jul 17, 2019·Current Medicinal Chemistry·Haralambos TzoupisTheodore Tselios

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.