NEWS2 is Superior to qSOFA in Detecting Sepsis with Organ Dysfunction in the Emergency Department

Journal of Clinical Medicine
Lisa MellhammarFredrik Kahn

Abstract

Early administration of antibiotics is associated with better survival in sepsis, thus screening and early detection for sepsis is of clinical importance. Current risk stratification scores used for bedside detection of sepsis, for example Quick Sequential Organ Failure Assessment (qSOFA) and National Early Warning Score 2 (NEWS2), are primarily validated for death and intensive care. The primary aim of this study was to compare the diagnostic accuracy of qSOFA and NEWS2 for a composite outcome of sepsis with organ dysfunction, infection-related mortality within <72 h, or intensive care due to an infection. Retrospective analysis of data from two prospective, observational, multicentre, convenience trials of sepsis biomarkers at emergency departments were performed. Cohort A consisted of 526 patients with a diagnosed infection, 288 with the composite outcome. Cohort B consisted of 645 patients, of whom 269 had a diagnosed infection and 191 experienced the composite outcome. In Cohort A and B, NEWS2 had significantly higher area under receiver operating characteristic curve (AUC), 0.80 (95% CI 0.75-0.83) and 0.70 (95% CI 0.65-0.74), than qSOFA, AUC 0.70 (95% CI 0.66-0.75) and 0.62 (95% CI 0.57-0.67) p < 0.01 and, p = 0.02, respe...Continue Reading

References

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Citations

Dec 10, 2019·British Medical Bulletin·Eleanor MitchellAnthony Roberts
Oct 21, 2020·Asia-Pacific Journal of Clinical Oncology·Tze Lui KohRichard Khor
Jan 29, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·F MorettoL Piroth
Jan 7, 2021·Resuscitation Plus·Aleksander Rygh HoltenKristian Tonby
May 30, 2021·Postgraduate Medical Journal·Charles CoughlanCéire E Costelloe
May 18, 2021·Journal of Clinical Tuberculosis and Other Mycobacterial Diseases·Mia Elhidsi Prasenohadi
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Oct 22, 2021·Critical Care Explorations·Scott C BrakenridgeLyle L Moldawer
Dec 11, 2021·Nursing in Critical Care·Zhen LuoLingli Peng

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Methods Mentioned

BETA
blood drawn
enzyme-linked immunosorbent assay

Software Mentioned

qSOFA
NEWS
clinfun
epiR
SPSS
grid
NEWS2
gridExtra
ggplot2
pROC

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