PMID: 7545978Dec 1, 1994Paper

NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons

Mechanisms of Development
A Bartholomä, K A Nave

Abstract

Mutations affecting peripheral nervous system development in Drosophila and mouse indicate that neural differentiation depends on the coordinated expression of cell type-specific bHLH proteins. We have identified a novel bHLH gene, termed NEX-1, which is expressed exclusively and abundantly in the mammalian central nervous system. By in situ hybridization, induction of the rodent NEX-1 gene coincides with the generation of postmitotic neurons and parallels overt neuronal differentiation and synaptogenesis. Unexpected for bHLH proteins, NEX-1 may play a role in neuronal function throughout adult life. High levels of its mRNA are sustained in mature pyramidal neurons of the hippocampus, cerebellum and several neocortical areas previously associated with learning and memory formation. When ectopically expressed in PC12 cells, NEX-1 transactivates the promoter of its own gene. This suggests that positive autoregulation stabilizes the activity of NEX-1 and its target genes in subsets of mature neurons.

References

Apr 1, 1992·Trends in Genetics : TIG·M Buckingham
Oct 1, 1992·Nature·L KretznerR N Eisenman
Jun 1, 1992·Trends in Genetics : TIG·S Campuzano, J Modolell
Feb 1, 1992·Current Opinion in Neurobiology·S K McConnell
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C G BegleyI R Kirsch
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·H VaessinY N Jan
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C G BegleyI R Kirsch
Feb 1, 1989·The Journal of Cell Biology·M Kozak
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H WeintraubA D Miller
Nov 4, 1988·Cell·M A Kuziora, W McGinnis
Oct 20, 1988·Nature·M Ptashne
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Feb 1, 1993·Current Opinion in Neurobiology·D J Anderson
Jan 1, 1993·Annual Review of Physiology·C H Bailey, E R Kandel

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Citations

Apr 1, 1997·Journal of Molecular Neuroscience : MN·D LeiferK Wehr
Nov 10, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Meenakshi RoyRobert Wayne
May 18, 2000·Brain Research. Molecular Brain Research·H OdaH Ohkubo
Feb 1, 1997·Current Opinion in Neurobiology·J E Lee
May 7, 1998·The International Journal of Biochemistry & Cell Biology·R KageyamaK Tomita
Dec 28, 2007·Molecular and Cellular Biology·Pierre MattarCarol Schuurmans
Apr 11, 2000·Molecular and Cellular Biology·H P HuangM J Tsai
Jan 11, 2002·Molecular and Cellular Biology·Markus Krüger, Thomas Braun
Aug 18, 2004·Molecular and Cellular Biology·Damian BrockschniederDieter Riethmacher
Sep 24, 2008·BMC Developmental Biology·Balázs V VargaBalázs Herberth
Aug 22, 2012·Neural Development·Tarek ShakerCarol Schuurmans
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·M LiuD H Lowenstein
Nov 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sheng-Xi WuNobuaki Tamamaki
Oct 3, 2002·Journal of Genetics·Lingchen GuoYumin Mao
Dec 6, 1997·Current Opinion in Genetics & Development·R Kageyama, S Nakanishi
Aug 2, 2011·Cellular and Molecular Life Sciences : CMLS·Beate GeistRobert Nitsch
Jul 23, 2008·Journal of Neurochemistry·Misa YamadaMitsuhiko Yamada
Apr 29, 2014·The Journal of Comparative Neurology·Taku SugiyamaYu Katsuyama
Jul 18, 2009·Journal of Neuroscience Research·Martine UittenbogaardAnne Chiaramello
Aug 9, 2005·Biochemical and Biophysical Research Communications·Hisanobu OdaHiroaki Ohkubo
Dec 10, 1999·Experimental Cell Research·F Guillemot
Feb 4, 2003·Journal of Neurochemistry·Martine UittenbogaardAnne Chiaramello
Dec 9, 2004·Journal of Neurochemistry·Martine Uittenbogaard, Anne Chiaramello
Dec 6, 2006·Genesis : the Journal of Genetics and Development·Sandra GoebbelsKlaus-Armin Nave
Jun 13, 1998·Developmental Biology·S Verma-KurvariJ E Johnson
Jan 1, 1997·Molecular and Cellular Neurosciences·M J RossnerK A Nave
May 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Yasuhiro ItohYukiko Gotoh
Jun 25, 2016·The Journal of Comparative Neurology·Ana Gutiérrez-RodríguezPedro Grandes

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