Next-generation and further transgenerational effects of bisphenol A on zebrafish reproductive tissues

Heliyon
Afroza AkhterToshinobu Tokumoto

Abstract

Next-generation effects and further transgenerational effects of an endocrine disruptor, bisphenol A (BPA), were investigated in zebrafish. The effects of BPA treatment through dietary administration in male and female zebrafish on reproductive factors, such as gonadal activity, fertility, hatching rate and malformation in subsequent generations, were examined through the third filial (F3) generation. BPA treatment of initial generation (F0) not only caused retraction of the ovaries and testes but also lowered the survival rate and increased the rate of malformation of the offspring. Although the overall phenotypes of the surviving first filial (F1) generation offspring of treated fish initially appeared to be normal, we found abnormalities in their reproductive tissues after they matured to adulthood. Although the juveniles were fed a normal diet, the ovaries of 40% of the F1 generation fish remained small and did not develop vitellogenic oocytes. Moreover, sterile male fish appeared at a higher percentage (48%) than control (10%). Adverse transgenerational effects on the fecundity of the second filial (F2) and F3 generation fish were also observed. In each generation, survival rate of embryos were significantly low and abnorm...Continue Reading

Citations

May 28, 2019·Journal of Developmental Origins of Health and Disease·Douglas Lopes AlmeidaPaulo Cezar de Freitas Mathias
Jul 6, 2020·The Journal of Experimental Biology·Naim M BautistaWarren Burggren
Aug 28, 2020·Frontiers in Endocrinology·Federica CariatiIda Strina
Sep 19, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mingxin ShiKanako Hayashi
Dec 8, 2019·Journal of Ethnopharmacology·Beatriz Martins de Sá HyacienthJosé Carlos Tavares Carvalho
Feb 22, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Hyekyoung Hannah You, Gwonhwa Song
Apr 12, 2021·Journal of Hazardous Materials·Md Saidur RahmanMyung-Geol Pang

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Methods Mentioned

BETA
transgenic
fluorescence microscopy

Software Mentioned

GraphPad Prism

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