Next-generation antibodies for post-translational modifications

Current Opinion in Structural Biology
Takamitsu Hattori, Shohei Koide

Abstract

Despite increasing demands for antibodies to post-translational modifications (PTMs), fundamental difficulties in molecular recognition of PTMs hinder the generation of highly functional anti-PTM antibodies using conventional methods. Recently, advanced approaches in protein engineering and design that have been established for biologics development were applied to successfully generating highly functional anti-PTM antibodies. Furthermore, structural analyses of anti-PTM antibodies revealed unprecedented binding modes that substantially increased the antigen-binding surface. These features deepen the understanding of mechanisms underlying specific recognition of PTMs, which may lead to more effective approaches for generating anti-PTM antibodies with exquisite specificity and high affinity.

Citations

Sep 7, 2019·The Journal of Physiology·Florian I Schmidt
Mar 20, 2020·Parasite Immunology·Mara Gutiérrez-SánchezSaul Rojas-Hernández
Aug 28, 2020·Frontiers in Cell and Developmental Biology·William A Scott, Eric I Campos
Dec 12, 2020·The Journal of Biological Chemistry·Misaki IshiiKouhei Tsumoto
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Feb 11, 2021·The Biochemical Journal·Bethany C Taylor, Nicolas L Young
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