Next-generation biocontainment systems for engineered organisms

Nature Chemical Biology
Jeong Wook LeeJames J Collins

Abstract

The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in biocontainment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation.

References

Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P BergM F Singer
Jun 16, 1975·Science·P BergM F Singer
Jan 1, 1991·Applied and Environmental Microbiology·S M Knudsen, O H Karlström
Oct 1, 1988·Applied and Environmental Microbiology·A K BejR M Atlas
Jun 10, 1998·Microbiology and Molecular Biology Reviews : MMBR·G del SolarR Díaz-Orejas
Oct 10, 1998·Journal of Virology·T DullL Naldini
May 26, 2001·Applied and Environmental Microbiology·M C Ronchel, J L Ramos
Sep 18, 2001·Proceedings of the National Academy of Sciences of the United States of America·D E Stanley-HornL Lewis
Sep 18, 2001·Proceedings of the National Academy of Sciences of the United States of America·M K SearsG P Dively
Jan 1, 1993·Accountability in Research·Debra J Wilson
Jun 4, 2002·Nature Biotechnology·Allison A Snow
May 1, 1991·Applied and Environmental Microbiology·A ContrerasJ L Ramos
Jan 24, 2006·Journal of Bacteriology·Masaru YaguraTateo Itoh
May 24, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Henri BraatLothar Steidler
Mar 16, 2007·Trends in Plant Science·Melissa J HillsAllen G Good
Jun 27, 2007·Nature Biotechnology·Kaihang WangJason W Chin
Apr 17, 2010·Nature Reviews. Genetics·Ahmad S Khalil, James J Collins
Aug 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jarred M CalluraJames J Collins
Jun 29, 2011·Angewandte Chemie·Philippe MarlièreRupert Mutzel
Aug 3, 2011·Antimicrobial Agents and Chemotherapy·Marta Colomer-LluchMaite Muniesa
Aug 27, 2011·Current Opinion in Microbiology·Timothy K Lu, Michael S Koeris
Mar 3, 2012·Nature·Genya V DanaAllison A Snow
Apr 21, 2012·Science·Vitor B PinheiroPhilipp Holliger
May 19, 2012·Nature Chemical Biology·Jeong Wook LeeSang Yup Lee
Oct 13, 2012·RNA Biology·Sylvain DurandSabine Brantl
Jan 29, 2013·Frontiers in Microbiology·Gerd H G Moe-BehrensKarmella A Haynes
Mar 23, 2013·Microbiology·Oliver WrightTom Ellis
Oct 19, 2013·Science·Marc J LajoieFarren J Isaacs
Apr 2, 2014·Nature Reviews. Microbiology·D Ewen CameronJames J Collins
Apr 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Michael T MeeHarris H Wang
May 9, 2014·Nature·Denis A MalyshevFloyd E Romesberg
May 23, 2014·ACS Synthetic Biology·Oliver WrightTom Ellis
Jun 9, 2014·Nature Chemical Biology·Naohiro TerasakaHiroaki Suga
Sep 23, 2014·Nature Biotechnology·Robert J CitorikTimothy K Lu
Oct 6, 2014·Nature Biotechnology·David BikardLuciano A Marraffini
Oct 17, 2014·Biotechnology Journal·Quentin M DudleyMichael C Jewett
Nov 25, 2014·Cell·Keith PardeeJames J Collins

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Citations

Dec 21, 2019·Biotechnology Journal·Austin G RottinghausTae Seok Moon
Jul 29, 2020·Molecular Plant-microbe Interactions : MPMI·Erna DenkovskienėAušra Ražanskienė
Nov 5, 2019·Frontiers in Bioengineering and Biotechnology·Khushal KhambhatiVijai Singh
Apr 2, 2020·Nature Biotechnology·Mao TaketaniChristopher A Voigt
Apr 29, 2020·Biotechnology and Bioengineering·Timothy A WhiteheadIan Wheeldon
Apr 28, 2019·The Journal of Experimental Medicine·Miguel JimenezGiovanni Traverso
Sep 13, 2019·Nucleic Acids Research·Jonathan CallesDrew Endy
Sep 25, 2019·Nature Reviews. Microbiology·Christopher E LawsonKatherine D McMahon
Feb 8, 2019·Critical Reviews in Biotechnology·Benjamin D TrumpIgor Linkov
Apr 10, 2020·Nature Communications·Mark R CharbonneauCaroline B Kurtz
Mar 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Catherine FanWei E Huang
Jul 15, 2020·Nature Biotechnology·Volker WiebkingMatthew H Porteus
May 22, 2020·Biotechnology and Bioengineering·Peng ZhaoTianwei Tan
Apr 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Tetsuhiro HarimotoTal Danino
Aug 10, 2019·BMC Biology·Aidan TinafarKeith Pardee
Nov 25, 2020·The ISME Journal·Timothy L HaskettPhilip S Poole
Nov 25, 2020·Chembiochem : a European Journal of Chemical Biology·Markus Schmidt, Vladimir Kubyshkin
Apr 19, 2020·Current Opinion in Biotechnology·Nikhil AggarwalMatthew Wook Chang
May 6, 2019·Biotechnology Advances·Peng-Fei XiaMatthew Wook Chang
Mar 13, 2021·ACS Synthetic Biology·Juan F Quijano, Ozgur Sahin
Nov 18, 2020·Current Opinion in Biotechnology·Kent M RappMichael J Betenbaugh
Apr 12, 2019·Current Opinion in Biotechnology·Arlinda RezhdoJames A Van Deventer
Mar 23, 2021·Trends in Genetics : TIG·Ethan Bier, Victor Nizet
Apr 7, 2021·Nature Chemical Biology·Tzu-Chieh TangTimothy K Lu
Nov 11, 2020·Journal of Bacteriology·Robert W P Glowacki, Eric C Martens
Dec 9, 2020·Biotechnology Advances·Jonas De SaegerStephen Depuydt
Jun 7, 2021·Current Opinion in Biotechnology·Kathleen L ArnoldsMichael T Guarnieri
Jun 19, 2021·Advanced Science·Daniel P BirnbaumNeel S Joshi
Jun 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Peter J VoorheesSamuel K Lai
Jul 18, 2021·Advanced Drug Delivery Reviews·Adriana Mejía-PittaCesar de la Fuente-Nunez
Mar 31, 2021·Annual Review of Biomedical Engineering·Patrick A LeggieriOphelia S Venturelli
Jul 31, 2021·Nature Biomedical Engineering·Tiffany ChienTal Danino
Jul 29, 2021·Microbiology Spectrum·Masahito IshikawaKatsutoshi Hori
Nov 24, 2020·ACS Chemical Biology·Rudy Rubini, Clemens Mayer
Jan 8, 2021·Journal of Agricultural and Food Chemistry·Hyun Jeong LeeHan Min Woo

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Methods Mentioned

BETA
transgenic
of
GMO

Software Mentioned

GeneGuard

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