Next-Generation COVID-19 Vaccines Should Take Efficiency of Distribution into Consideration.

AAPS PharmSciTech
Khaled AboulFotouhRobert O Williams

Abstract

The dire need for safe and effective coronavirus disease (COVID-19) vaccines is met with many vaccine candidates being evaluated in pre-clinical and clinical studies. The COVID-19 vaccine candidates currently in phase 3 or phase 2/3 clinical trials as well as those that recently received emergency use authorization (EUA) from the United States Food and Drug Administration (FDA) and/or other regulatory agencies worldwide require either cold (i.e., 2-8°C) or even freezing temperatures as low as -70°C for storage and distribution. Thus, existing cold chain will struggle to support both the standard national immunization programs and COVID-19 vaccination. The requirement for cold chain is now a major challenge towards worldwide rapid mass vaccination against COVID-19. In this commentary, we stress that thermostabilizing technologies are available to enable cold chain-free vaccine storage and distribution, as well as potential needle-free vaccination. Significant efforts on thermostabilizing technologies must now be applied on next-generation COVID-19 vaccines for more cost-effective worldwide mass vaccination and COVID-19 eradication.

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Clinical Trials Mentioned

NCT04475302
NCT04379336
NCT04368988
NCT04336410
NCT04449276
NCT04368728
NCT04470427
NCT04641481
NCT04582344
NCT04352608

Software Mentioned

CanSinoBio
Moderna

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