Next-Generation Novel Noninvasive Cancer Molecular Diagnostics Platforms Beyond Tissues

American Society of Clinical Oncology Educational Book
Xiaoliang WuPatrick C Ma

Abstract

In recent years, there has been a revolutionary expansion in technologic advances and therapeutic innovations in cancer medicine. Cancer diagnostics has begun to move away from a sole dependence on direct tumor tissue biopsy for cancer detection, diagnosis, and treatment monitoring. The need for improvement in molecular cancer diagnostics has never been more important, with not only the advent of cancer genomics and genomics-guided precision medicine but also the recent arrival of cancer immunotherapies. Owing to the practical limitations and risks associated with tissue-based biopsy diagnostics, novel noninvasive cancer diagnostics platforms have continued to evolve and expand in recent years. Examples of these platforms include the liquid biopsy, which is used to interrogate ctDNA or circulating tumor cells, proteomics, metabolomics, and exosomes; the urine biopsy, which is used to assay ctDNAs; saliva and stool biopsies, which are used for molecular genomics assays; and the breath biopsy, which measures volatile organic compounds. These next-generation noninvasive molecular diagnostics assays beyond tissues fundamentally transform the potential utilities of cancer diagnostics to enable repeat, prospective, and serial longitu...Continue Reading

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Citations

Jul 10, 2019·Journal of Breath Research·Annalisa CampanellaStefania Tommasi
Sep 10, 2020·Cancers·Sabine Kasimir-Bauer On Behalf Of The Ovcad Ovarian Cancer Diagnosis Initiative
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Joana MaiaBruno Costa-Silva
Oct 4, 2019·New Biotechnology·Francesca SalviantiPamela Pinzani

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