Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: emphasis on the relationship with hepatoid adenocarcinoma

Human Pathology
Yoichi AkazawaTakashi Yao

Abstract

Histologically tubulopapillary structures with glycogen-rich clear cytoplasm in gastric adenocarcinoma with enteroblastic differentiation (GAED) are well known, but a solid growth pattern can also be observed as a minor component. In contrast, hepatoid adenocarcinoma (HAC) of the stomach shows many overlapping features, including solid pattern and α-fetoprotein expression. In this study, we employed next-generation sequencing (NGS) to establish a molecular/clinicopathological concept of GAED and clarify whether these two tumors should be grouped together in one category. Among 2273 primary gastric cancers treated in our hospital between 2008 and 2017, we defined 51 cases as GAEDs showing tubulopapillary or solid patterns that express at least one of the following markers: α-fetoprotein, glypican-3, or spalt-like transcription factor 4. All cases previously diagnosed as HAC in our hospital had clear cytoplasm and were included as GAEDs by histological re-evaluation and immunohistochemical findings. We performed NGS for 24 histologically typical GAEDs and Sanger sequencing for the remaining cases. The most frequently mutated gene was TP53, and almost all cases with missense mutation showed p53 overexpression. An analysis of copy ...Continue Reading

Citations

Mar 9, 2019·The American Journal of Gastroenterology·Shingo OgiwaraTaro Osada
Aug 25, 2019·Virchows Archiv : an International Journal of Pathology·Sho TsuyamaTakashi Yao
Aug 22, 2020·Virchows Archiv : an International Journal of Pathology·Yuka YanaiTakashi Yao
Apr 17, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yakun WangXiaotian Zhang
Dec 17, 2018·Virchows Archiv : an International Journal of Pathology·Noboru YatagaiTakashi Yao
Mar 13, 2021·Scientific Reports·Yuya YamashiroTsuyoshi Saito
Apr 30, 2021·Frontiers in Oncology·Ruolan XiaXuelei Ma
Dec 7, 2021·Pediatric Blood & Cancer·Adeline YangDinesh Rakheja
Dec 5, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jun LuXingran Jiang

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