Next-generation sequencing: hype and hope for development of personalized radiation therapy?

Radiation Oncology
Ingeborg TinhoferVolker Budach

Abstract

The introduction of next-generation sequencing (NGS) in the field of cancer research has boosted worldwide efforts of genome-wide personalized oncology aiming at identifying predictive biomarkers and novel actionable targets. Despite considerable progress in understanding the molecular biology of distinct cancer entities by the use of this revolutionary technology and despite contemporaneous innovations in drug development, translation of NGS findings into improved concepts for cancer treatment remains a challenge. The aim of this article is to describe shortly the NGS platforms for DNA sequencing and in more detail key achievements and unresolved hurdles. A special focus will be given on potential clinical applications of this innovative technique in the field of radiation oncology.

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Citations

Jul 14, 2016·Expert Opinion on Biological Therapy·Neha KamranMaria G Castro
Jul 30, 2019·Medical Physics·Theodor AsaveiPaul R Vasos

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Methods Mentioned

BETA
exome sequencing
electrophoresis
in-silico methods
dissection
immunoprecipitation
biopsy

Software Mentioned

MutSig
SIFT
assessor
PolyPhen
MutSigv2
mutation
Mutation Assessor
PolypPhen

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