Next-Generation Sequencing in 305 Consecutive Patients: Clinical Outcomes and Management Changes

Journal of Oncology Practice
William DavisGregory J Kubicek

Abstract

Next-generation sequencing (NGS) is increasingly used to identify actionable mutations for oncology treatment. We examined the results and use of NGS assays at our institution. We retrospectively reviewed the medical records of 305 consecutive patients who had NGS testing of tumor samples from March 2014 to April 2017. NGS was performed by FoundationOne. Of the 305 tissue samples sent to FoundationOne, 189 reports were potentially usable. Of these reports, 76 (40.21%) demonstrated an aberration targetable by on-label therapies and 126 (66.67%) by off-label therapies, and 170 (89.94%) revealed actionable aberrations via all potential avenues, including clinical trials; 21 of these 189 potentially usable reports (11.1%) yielded a change in management, including use of on-label therapies (n = 7), use of off-label therapies (n = 6), enrollment in a clinical trial (n = 6), and discontinuation of a medication with a predicted poor response (n = 3; one report was used twice). For the six patients with off-label use, median duration of treatment was 46 days and discontinued after death (n = 3) or progression (n = 3). Only a minority of NGS assay results (6.9% percent of all tests ordered and 11.1% of useable tests) resulted in a manage...Continue Reading

References

Apr 9, 2015·Molecular Cancer Therapeutics·Maria SchwaederleRazelle Kurzrock
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