Next-Generation Sequencing of Synchronous Multiple Primary Lung Cancers in a Patient with Squamous Cell Carcinoma and Small Cell Lung Cancer

OncoTargets and Therapy
Xinggang WuYutao Wei

Abstract

The incidence of synchronous multiple primary malignancies is low. The presence of different lung tumor types in one patient is rare. Here, we report a rare case of synchronous lung squamous cell cancer and small cell lung cancer in a 60-year-old man. Because of the presence of two different tumor types, the proper treatment must be determined. To identify treatment targets, the genetic features of primary tumor tissues from the lungs were analyzed by next-generation sequencing (NGS). The objective was to analyze the origin and evolution of multiple primary lung cancers. NGS can find the genetic mutation sites of patients to guide treatment and promote the advancement of precision medicine. The effects of standard treatments were evaluated by response evaluation criteria in solid tumors. The results suggest that early treatment of synchronous multiple primary malignancies is a favorable outcome.

References

Aug 21, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Elisabetta FroioGuido Rindi
Jun 3, 2016·Scientific Reports·Zhirong ZhangJie He
Sep 8, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hong Sook KimSe-Hoon Lee
Nov 26, 2019·The Annals of Thoracic Surgery·Xiaozheng KangKe-Neng Chen

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BETA
biopsies
biopsy

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