NF-κB activation contributes to parathyroid cell proliferation in chronic kidney disease.

Journal of Nephrology
Sen KanJing Chen

Abstract

Secondary hyperparathyroidism is characterized by parathyroid gland (PG) hyperplasia, and excessive synthesis and secretion of parathyroid hormone (PTH). Reduced vitamin D receptor (VDR) density has shown to play an essential role in PG hyperplasia progression; nevertheless, its exact mechanism remains unclear. VDR has shown to suppress the inflammation mediator NF-κB-mediated gene transcription. The aim of this study is to examine whether NF-κB is involved in the pathogenesis of parathyroid hyperplasia. 35 PGs was obtained from 10 maintenance hemodialysis patients who underwent parathyroidectomy surgery. 5/6-nephrectomized rats fed with a high-phosphate diet were divided into four groups: (1) Nx + vehicle group, treated with vehicle; (2) Nx + PDTC prevention group, treated with NF-κB inhibitor PDTC for 2 months; (3) Nx + PDTC therapy group, treated with PDTC for 1 month; (4) Nx + calcitriol group, treated with activated vitamin D calcitriol for 1 month. Ten sham-operated rats fed with normal-phosphate diet were used as a control group. Serum calcium, phosphorus, creatinine, Blood urea nitrogen (BUN), intact PTH and PG size in rats were measured. Proliferating cell nuclear antigen (PCNA), VDR, NF-κB of PGs were examined using i...Continue Reading

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Citations

Jun 24, 2020·International Journal of Molecular Sciences·Tally Naveh-Many, Oded Volovelsky
Sep 12, 2020·F1000Research·María E Rodríguez-Ortiz, Mariano Rodríguez
Jan 23, 2019·Bioscience, Biotechnology, and Biochemistry·Zhiwen JiangXinguang Liu
Apr 3, 2020·Molecular Biology Reports·George I LambrouSpiros Vlahopoulos
Feb 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lili YangFengxiang Wei
Jul 27, 2021·Scandinavian Journal of Gastroenterology·Jun-Yan JiangMao-Xia Liu

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