NF-κB Essential Modulator (NEMO) Is Critical for Thyroid Function.

The Journal of Biological Chemistry
Carla RealeRomania Stilo

Abstract

The I-κB kinase (IKK) subunit NEMO/IKKγ (NEMO) is an adapter molecule that is critical for canonical activation of NF-κB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis, and apoptosis. To explore the functional role of canonical NF-κB signaling in thyroid gland differentiation and function, we have generated a murine strain bearing a genetic deletion of the NEMO locus in thyroid. Here we show that thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span. Histological and molecular analysis indicate that absence of NEMO in thyrocytes results in a dramatic loss of the thyroid gland cellularity, associated with down-regulation of thyroid differentiation markers and ongoing apoptosis. Thus, NEMO-dependent signaling is essential for normal thyroid physiology.

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Citations

Feb 6, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ana Paula Cremasco TakanoMaria Luiza Morais Barreto-Chaves
Oct 3, 2018·Frontiers in Physiology·Anna IervolinoFrancesco Trepiccione
Sep 7, 2018·Frontiers in Endocrinology·Cesidio GiulianiGiorgio Napolitano
Sep 17, 2020·Thyroid : Official Journal of the American Thyroid Association·Romina Celeste GeyselsJuan Pablo Nicola
Nov 14, 2021·Microbial Biotechnology·Lucrezia ZerilloTiziana Zotti

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