NF-κB-IKKβ Pathway as a Target for Drug Development: Realities, Challenges and Perspectives

Current Drug Targets
Rosana H C N Freitas, Carlos A M Fraga

Abstract

Nuclear factor κB (NF-κB) comprises a family of proteins that act as transcription factors promoting the expression of many genes. Activation of NF-κB biochemical cascades is associated with the regulation of innate and adaptive immune responses and inflammation, among other physiological responses. However, genetic abnormalities and continuous stimulation of the NF- κB-IKKβ pathway are directly related to many types of inflammatory and autoimmune diseases, as well as to the genesis and survival of tumor cells. Inhibition of the NF-κB-IKKβ cascade can be considered an attractive therapeutic method for the genesis of new prototypes to combat these chronic multifactorial diseases. This review describes some prototypes and drugs that act to inhibit the NF-κB-IKKβ pathway, highlighting the realities, challenges and perspectives for therapeutic use. Although only proteasome inhibitors, such as bortezomib and carfilzomib, are a reality as therapeutically useful drugs among the known modulators of possible targets in the NF-κB-IKKβ pathway, some other prototypes described as IKKβ inhibitors have entered clinical stages as drug candidates for the control of inflammatory diseases. It is important to note that some classical drugs availa...Continue Reading

Citations

Jun 18, 2020·The Journal of Pharmacology and Experimental Therapeutics·Natália CordeiroPatricia Dias Fernandes
Jul 10, 2019·Journal of the American Society of Nephrology : JASN·Sonia ZambranoJaakko Patrakka
Jan 16, 2021·International Journal of Molecular Sciences·Laura BaumgartnerJérôme Noailly
Aug 5, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rajan Radha RasmiChandrasekaran Guruvayoorappan
Aug 28, 2021·Biomedicines·Supattra ChaithongyotMichael Naumann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.