NF-κB signaling in cancer stem cells: a promising therapeutic target?

Cellular Oncology (Dordrecht)
K Vazquez-SantillanV Maldonado

Abstract

Cancer stem cells (CSCs) are regulated by several signaling pathways that ultimately control their maintenance and expansion. NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) forms a protein complex that controls DNA transcription and, as such, plays an important role in proliferation, inflammation, angiogenesis, invasion and metastasis. The NF-κB signaling pathway, which has been found to be constitutively activated in CSCs from a variety of cancers, participates in the maintenance, expansion, proliferation and survival of CSCs. Targeted disruption of this pathway may profoundly impair the adverse phenotype of CSCs and may provide a therapeutic opportunity to remove the CSC fraction. In particular, it may be attractive to use specific NF-κB inhibitors in chronic therapeutic schemes to reduce disease progression. Exceptional low toxicity profiles of these inhibitors are a prerequisite for use in combined treatment regimens and to avoid resistance. Although still preliminary, recent evidence shows that such targeted strategies may be useful in adjuvant chemo-preventive settings.

References

May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·L LingD V Goeddel
Nov 2, 2001·Nature·T ReyaI L Weissman
Feb 21, 2002·Journal of the National Cancer Institute·Michael J ThunCarlo Patrono
Nov 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Monica L GuzmanCraig T Jordan
Feb 18, 2004·Current Cancer Drug Targets·Chinthalapally V Rao, Bandaru S Reddy
May 4, 2004·Nature Reviews. Cancer·Julian Adams
Jun 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Debajit K BiswasJ Dirk Iglehart
Sep 17, 2004·Genes & Development·Matthew S Hayden, Sankar Ghosh
Apr 2, 2005·Nature Reviews. Cancer·Chikashi Nakanishi, Masakazu Toi
Apr 28, 2005·Virchows Archiv : an International Journal of Pathology·Xavier DolcetXavier Matias-Guiu
Dec 6, 2005·Nature Reviews. Cancer·Rolf BjerkvigA J A Terzis
May 5, 2006·Molecular Carcinogenesis·Michael Karin
Jan 19, 2007·The New England Journal of Medicine·Rui LiuMichael F Clarke
Mar 14, 2007·Cancer Cell·Michail ShipitsinKornelia Polyak
Jul 25, 2007·Annual Review of Cell and Developmental Biology·Neethan A LoboMichael F Clarke
Sep 19, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hwee-Luan Ang, Vinay Tergaonkar
Sep 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yixue CaoMichael Karin
Oct 30, 2007·Breast Cancer Research and Treatment·Jiangbing ZhouYing Zhang
Feb 13, 2008·Cell·Matthew S Hayden, Sankar Ghosh
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eyal C AttarPhilip C Amrein
Apr 29, 2008·Current Opinion in Genetics & Development·Willscott E Naugler, Michael Karin
Jun 16, 2009·Apoptosis : an International Journal on Programmed Cell Death·A-Mi SeoMyeong-Sok Lee
Feb 27, 2010·PLoS Biology·Anita B HjelmelandJeremy N Rich

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Citations

Apr 30, 2016·Cellular Oncology (Dordrecht)·Roman Paduch
Jun 17, 2016·Cellular Oncology (Dordrecht)·Meixiang XuSherif Z Abdel-Rahman
Aug 27, 2016·Cellular Oncology (Dordrecht)·Vignesh RameshKumaresan Ganesan
Sep 30, 2016·Cellular Oncology (Dordrecht)·Antonieta Chavez-GonzalezSadegh Babashah
Jan 31, 2018·Nature Reviews. Immunology·Koji Taniguchi, Michael Karin
Mar 29, 2018·Cellular & Molecular Biology Letters·Michaela GaloczovaBorivoj Vojtesek
Sep 21, 2017·Cellular Oncology (Dordrecht)·Betul TaskoparanSreeparna Banerjee
Sep 16, 2018·Cellular Oncology (Dordrecht)·Rosario Castro-OropezaKarla Vazquez-Santillan
Dec 9, 2017·The Journal of Pharmacology and Experimental Therapeutics·Narumol BhummaphanPithi Chanvorachote
Jul 6, 2017·Cellular Oncology (Dordrecht)·Preeyaporn Plaimee Phiboonchaiyanan, Pithi Chanvorachote
Jul 28, 2017·Cellular Oncology (Dordrecht)·Georgios S MarkopoulosEvangelos Kolettas
Aug 28, 2020·Scientific Reports·Rosario Castro-OropezaVilma Maldonado
Mar 26, 2020·The Science of the Total Environment·Ayesha SarfrazAzhar Rasul
Sep 3, 2020·Seminars in Cancer Biology·Sabah AkhtarHesham M Korashy
May 1, 2021·International Journal of Molecular Sciences·Brock HumphriesChengfeng Yang
Jul 17, 2021·The Biochemical Journal·Jack A PrescottSimon J Cook

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