NF-kappaB in renal inflammation

Journal of the American Society of Nephrology : JASN
Ana Belen SanzAlberto Ortiz

Abstract

The NF-kappaB family of transcription factors regulates the induction and resolution of inflammation. Two main pathways, classical and alternative, control the nuclear translocation of NF-kappaB. Classical NF-kappaB activation is usually a rapid and transient response to a wide range of stimuli whose main effector is RelA/p50. The alternative NF-kappaB pathway is a more delayed response to a smaller range of stimuli resulting in DNA binding of RelB/p52 complexes. Additional complexity in this system involves the posttranslational modification of NF-kappaB proteins and an ever-increasing range of co-activators, co-repressors, and NF-kappaB complex proteins. Collectively, NF-kappaB regulates the expression of numerous genes that play a key role in the inflammatory response during human and experimental kidney injury. Multiple stimuli activate NF-kappaB through the classical pathway in somatic renal cells, and noncanonical pathway activation by TWEAK occurs in acute kidney injury. Under most test conditions, specific NF-kappaB inhibitors tend to reduce inflammation in experimental kidney injury but not always. Although many drugs in current use clinically influence NF-kappaB activation, there are no data regarding specific NF-kapp...Continue Reading

References

Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I H VosT J Rabelink
Jun 23, 2000·Journal of the American Society of Nephrology : JASN·Naruya TomitaToshio Ogihara
Feb 13, 2001·Kidney International·C Guijarro, J Egido
Aug 14, 2001·The Journal of Biological Chemistry·A J García-PiñeresI Merfort
Sep 29, 2001·Kidney International·S A MezzanoJ Egido
Dec 1, 2001·Nature Medicine·T LawrenceD A Willoughby
May 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Norihiko SakaiHitoshi Yokoyama
Oct 9, 2002·The American Journal of Pathology·Oscar López-FrancoCarmen Gómez-Guerrero
Mar 13, 2003·Kidney International·Osamu TakaseTakao Saruta
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mamiko AshizawaShigeru Kohno
Jul 4, 2003·The Journal of Biological Chemistry·Tatsuya SaitohShoji Yamaoka
Jul 25, 2003·Intensive Care Medicine·Salvatore CuzzocreaChristoph Thiemermann
Oct 9, 2003·The EMBO Journal·Alexander HoffmannDavid Baltimore
Apr 1, 2004·Molecular Cell·Kirsteen J CampbellNeil D Perkins
May 4, 2004·Nature Reviews. Molecular Cell Biology·Lin-Feng Chen, Warner C Greene
May 22, 2004·Journal of the American Society of Nephrology : JASN·Vanesa EstebanMarta Ruiz-Ortega
Jul 29, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sergio MezzanoJesús Egido
Sep 17, 2004·Genes & Development·Matthew S Hayden, Sankar Ghosh
Oct 7, 2004·Journal of the American Society of Nephrology : JASN·Antonia LoverreGiuseppe Grandaliano
Mar 31, 2005·American Journal of Physiology. Renal Physiology·Ulla HäusslerGünter Schneider
May 13, 2005·The Tohoku Journal of Experimental Medicine·Masateru IwamotoHiromichi Hemmi
Jun 25, 2005·Journal of the American Society of Nephrology : JASN·Michael J RossLeslie A Bruggeman
Sep 17, 2005·Science·Markus W CovertDavid Baltimore
Oct 6, 2005·American Journal of Physiology. Renal Physiology·Scott Martinka, Leslie A Bruggeman
Oct 6, 2005·Virchows Archiv : an International Journal of Pathology·Ling ZhengStephen I-Hong Hsu
Oct 14, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Evangelia SpandouDimitrios Tsakiris
Nov 11, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marta Ruiz-OrtegaJesús Egido
Apr 21, 2006·Immunological Reviews·Alexander Hoffmann, David Baltimore
Aug 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konstantin D TaganovDavid Baltimore
Aug 10, 2006·American Journal of Physiology. Renal Physiology·Clarice K FujiharaRoberto Zatz

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Citations

Nov 28, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Peter Y ChuangJohn C He
Sep 24, 2013·Molecular Biology Reports·Mohammad Reza AlipourFarhad Ghadiri Soufi
Feb 4, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alejandro Álvarez-PratsJosé C Rodríguez-Pérez
Oct 19, 2010·Mediators of Inflammation·Maria D Sanchez-NiñoAlberto Ortiz
Jun 16, 2012·International Journal of Nephrology·Jorge Rojas-RiveraJesus Egido
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Lixia YuJianming Ye
Apr 22, 2011·American Journal of Nephrology·Pablo E PergolaDavid G Warnock
Jan 10, 2013·PloS One·Alvaro C UceroAdrián M Ramos
Mar 7, 2014·PloS One·Ana Belen SanzAlberto Ortiz
Jul 2, 2011·Journal of the American Society of Nephrology : JASN·Juan A MorenoAna B Sanz
Oct 25, 2011·Journal of the American Society of Nephrology : JASN·Marpadga A Reddy, Rama Natarajan
Jun 9, 2012·Journal of the American Society of Nephrology : JASN·Ling LinKebin Hu
Jul 17, 2012·Journal of the American Society of Nephrology : JASN·Diane L Rosin, Mark D Okusa
May 11, 2011·Immunotherapy·Wenbo ZhangRuth B Caldwell
Oct 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jonay PovedaAlberto Ortiz
Sep 28, 2013·International Urology and Nephrology·Alvaro C UceroAlberto Ortiz
Feb 19, 2014·Expert Reviews in Molecular Medicine·Juan Antonio MorenoJesús Egido
May 8, 2014·Nature Reviews. Nephrology·Beatriz Fernandez-FernandezJesus Egido
Mar 5, 2014·Journal of Physiology and Biochemistry·Silvana L Della PennaBelisario E Fernández
Oct 12, 2012·Apoptosis : an International Journal on Programmed Cell Death·María del NogalLaura Calleros
Jan 28, 2014·Cell Biochemistry and Biophysics·Qianwei LiWeibing Li
Aug 5, 2015·Journal of Clinical Medicine·Maria Vanessa Perez-GomezBeatriz Fernandez-Fernandez
Jan 30, 2016·Journal of the American Society of Nephrology : JASN·Lajos MarkóDominik N Müller
Jun 24, 2011·Kidney International·Ana Belen SanzAlberto Ortiz
Aug 5, 2011·Kidney International·Jorge CerdáDavid G Warnock
Jan 3, 2016·European Journal of Pharmacology·Cheng-zhen LiSeong-ho Han
Dec 17, 2015·BMC Complementary and Alternative Medicine·Elizabeth Grunz-BorgmannAlan R Parrish
Mar 11, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Li-Chun HoYau-Sheng Tsai
Aug 1, 2015·Cell Stress & Chaperones·Luciana MazzeiWalter Manucha

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