NF-kappaB inhibition: a double-edged sword in cancer?

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Eli Pikarsky, Yinon Ben-Neriah

Abstract

Several recent studies of mouse models of cancer have provided direct genetic evidence for the critical role of NF-kappaB in carcinogenesis. While it has long been known that NF-kappaB is a key mediator of chemotherapy resistance, it is now clear that the transcription factor also has a major role in tumour development, particularly at its earlier phases. However, the role of NF-kappaB in tumourigenesis is more complex than anticipated, as in some models NF-kappaB inhibition blocks, whereas in others it facilitates, tumour development. In this paper we review current knowledge and suggest a general hypothesis that attempts to resolve this apparent paradox. Further cancer model studies should help to clarify this issue, complementing the intensive drug development effort of the pharmaceutical industry around NF-kappaB.

References

Nov 15, 1995·Genes & Development·I M VermaS Miyamoto
Jan 1, 1994·Annual Review of Cell Biology·U SiebenlistK Brown
Apr 10, 1997·The New England Journal of Medicine·P J Barnes, M Karin
Apr 1, 1997·Seminars in Cancer Biology·R M AttarR Bravo
Apr 1, 1997·Seminars in Cancer Biology·I Luque, C Gélinas
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·N Li, M Karin
Jul 8, 1999·Nature Medicine·N L Michael, J P Moore
Dec 22, 1999·Oncogene·B Rayet, C Gélinas
Jan 19, 2000·The Journal of Experimental Medicine·L M Staudt
Jun 3, 2000·Annual Review of Immunology·M Karin, Y Ben-Neriah
Jan 3, 2001·The Journal of Clinical Investigation·A S Baldwin
Feb 13, 2001·The Journal of Clinical Investigation·A S Baldwin
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·M Delhase, M Karin
Oct 29, 2002·Cellular Signalling·Susanne BellKorbinian Brand
Nov 15, 2002·Cancer Letters·Thomas GilmoreDaniel Starczynowski
Jan 1, 2003·Seminars in Cancer Biology·Sharon Amit, Yinon Ben-Neriah
Mar 26, 2003·Seminars in Cancer Biology·Anning Lin, Michael Karin
Sep 11, 2003·The Lancet Oncology·Peter W Szlosarek, Frances R Balkwill
Jan 16, 2004·Genes & Development·Jennifer Y ZhangPaul A Khavari
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Maria H LindInderpreet Sur
Apr 13, 2004·Oncogene·David Martín-OlivaF Javier Oliver
Jun 12, 2004·The Journal of Investigative Dermatology·Max van HogerlindenJohn P Sundberg
Aug 27, 2004·Nature·Eli PikarskyYinon Ben-Neriah
Feb 9, 2005·The Journal of Cell Biology·Jennifer Y ZhangPaul A Khavari
Apr 2, 2005·Nature Reviews. Cancer·Chikashi Nakanishi, Masakazu Toi

❮ Previous
Next ❯

Citations

Feb 5, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Gowrikumar SaiprasadGanapasam Sudhandiran
Feb 20, 2008·Angiogenesis·Sebastien P Tabruyn, Arjan W Griffioen
Jan 2, 2009·Journal of Natural Products·Ratnakar N AsolkarJohn M Pezzuto
Apr 19, 2007·Nature Immunology·Yinon Ben-Neriah, Marc Schmidt-Supprian
Jan 23, 2008·The Journal of Experimental Medicine·Christoffer GebhardtPeter Angel
Jun 19, 2007·Antioxidants & Redox Signaling·Eui Jung MoonMark W Dewhirst
Feb 27, 2010·PLoS Biology·Anita B HjelmelandJeremy N Rich
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Wenshu ChenYong Lin
Jul 10, 2010·International Journal of Environmental Research and Public Health·Valeriy Zaporozhan, Andriy Ponomarenko
Mar 14, 2012·Marine Drugs·Tamara P KondratyukJohn M Pezzuto
Apr 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Oliver M T PearceAjit Varki
Sep 10, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Marian KampschulteMartin Roderfeld
Jan 18, 2007·Expert Opinion on Therapeutic Targets·Davide Melisi, Paul J Chiao
Sep 23, 2010·Expert Opinion on Therapeutic Targets·Massimo Breccia, Giuliana Alimena
May 19, 2006·Expert Opinion on Therapeutic Targets·Anton Yuryev
Aug 9, 2011·Expert Opinion on Therapeutic Targets·Vanja VaccaroMichele Milella
Apr 2, 2008·Expert Review of Vaccines·Jeremy WalesMarc Feldmann
Apr 4, 2012·Differentiation; Research in Biological Diversity·Felicitas BergerBarbara Munz
May 19, 2009·Trends in Pharmacological Sciences·Gautam Sethi, Vinay Tergaonkar
May 16, 2008·Cancer Letters·Gilad W VainerYinon Ben-Neriah
Jul 6, 2007·BioFactors·Chae Hyeong LeeYong-Sang Song
Feb 3, 2007·Cancer Science·Jun-Ichiro InoueKentaro Semba
Aug 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaofeng SunSimon C Robson
Jun 16, 2010·Histopathology·Silvia Darb-EsfahaniCarsten Denkert
Sep 16, 2006·Biochemical Pharmacology·Sabine OlivierVincent Bours
Jul 19, 2006·Biochemical Pharmacology·Christoffer GebhardtJochen Hess
May 6, 2015·Journal of Hepatology·Jens U MarquardtSnorri S Thorgeirsson
Sep 26, 2013·ELife·Ainhoa Pérez-GarijoHermann Steller
Jul 23, 2011·Cellular Immunology·John J Haddad, Nisreen E Abdel-Karim
Mar 21, 2015·Endocrine-related Cancer·Maria Eugenia SabatinoAna Lucía De Paul
Feb 20, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoshiaki SunamiMathias Heikenwalder
Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Javad Sharifi-RadMarcello Iriti
Mar 29, 2018·Scientific Reports·Foteinos-Ioannis D DimitrakopoulosHaralabos P Kalofonos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis