NF-kappaB is involved in inhibition of lipoxin A4 on dermal inflammation and hyperplasia induced by mezerein

Experimental Dermatology
Sheng-Hua WuHong-Juan Wu

Abstract

The mechanisms by which lipoxin A(4) (LXA(4)) inhibit skin inflammation remain unclear. In the present studies, the ear inflammatory model was induced by topical application of mezerein. Treatment of the mouse ear with LXA(4) exhibited the inhibitory effects on oedema, neutrophil infiltration, vascular permeability, expressions of interleukin (IL)-1, IL-6 and IL-8 mRNA, DNA-binding activity of nuclear factor-kappaB (NF-kappaB), and on dermal hyperplasia. NF-kappaB reporter activities and nuclear translocations of NF-kappaB p65 in cultured keratinocytes stimulated by mezerein were inhibited by pretreatment of the cells with LXA(4). LXA(4) reduced degradation, but not phosphorylation of IkappaBalpha in cultured keratinocytes stimulated by mezerein, suggesting that LXA(4)-attenuated IkappaBalpha degradation may restore the mezerein-blocked inhibitory effects of IkappaB on nuclear translocation and DNA-binding activity of NF-kappaB. Our results demonstrated that LXA(4) displays the anti-inflammatory and anti-proliferative role on ear inflammatory model induced by mezerein and these effects were related with downregulation of DNA-binding activity of NF-kappaB.

References

May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew T GewirtzJames L Madara
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Levente JózsefJános G Filep
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Jun 19, 2008·Experimental Dermatology·Annesofie Faurschou, Robert Gniadecki
Sep 9, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Sheng-Hua WuZ-Q Chen

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Citations

Apr 23, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Xiao-Qing ChenYan-Rong Tang
Jul 28, 2012·The British Journal of Dermatology·S-H WuL Dong
Apr 22, 2015·European Journal of Pharmacology·Mario RomanoAntonio Recchiuti
Nov 5, 2014·Journal of Medicinal Chemistry·Olivier Corminboeuf, Xavier Leroy

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