NF-kappaB/PPAR gamma and/or AP-1/PPAR gamma 'on/off' switches and induction of CBP in colon adenocarcinomas: correlation with COX-2 expression

International Journal of Colorectal Disease
Panagiotis A KonstantinopoulosAthanasios G Papavassiliou

Abstract

Several studies indicate that peroxisome proliferator-activated receptor gamma (PPAR gamma) represses activator protein-1 (AP-1) and nuclear factor kappa B (NF-kappaB) transcriptional activity and this negative cross-talk occupies an important role in carcinogenesis. The present study evaluated the differential expression profile of AP-1 constituents (c-FOS and phosphorylated-active pc-JUN), p-I kappaB-alpha (phosphorylated I kappaB-alpha, a signaling intermediate of NF-kappaB pathway), PPAR gamma, cyclic AMP-response element binding-binding protein (CBP, a known AP-1, NF-kappaB, and PPAR gamma transcriptional coactivator), epidermal growth factor receptor (EGF-R), p53, and COX-2 in normal colonic epithelial cells and colon adenocarcinoma cells. Immunohistochemical methodology was performed on formalin-fixed, paraffin-embedded sections from 60 patients with colon adenocarcinomas. A molecular profile was created for each patient and the induction or down-regulation of each pathway from normal to cancer cells was documented. Relationships between transcription factors and downstream molecular targets were evaluated by Spearman's rho correlation coefficient and validated by nonparametric Kruskal-Wallis test. P-I kappaB-alpha (P<0....Continue Reading

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Citations

Jul 31, 2007·Journal of Cancer Research and Clinical Oncology·Ioannis A Voutsadakis
Sep 13, 2011·Archives of Pharmacal Research·Jeong Ah KimYoung Ho Kim
Oct 3, 2012·PPAR Research·Valerio PazienzaGianluigi Mazzoccoli
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Apr 28, 2019·International Journal of Molecular Sciences·Valeria TutinoMaria Notarnicola
Mar 12, 2020·International Journal of Nephrology·Yuhua MaJian Liu
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Nov 6, 2020·Molecular and Cellular Endocrinology·Silvana Rocío FerreiraAlicia Beatriz Motta

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