NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF.

The Journal of Biological Chemistry
R A Currie

Abstract

The ubiquitous transcription factor, NF-Y, plays a pivotal role in the cell cycle regulation of the mammalian cyclin A, cdc25C, and cdc2 genes, in the S-phase activation of the ribonucleotide reductase R2 gene, in addition to its critical role as a key proximal promoter factor in the transcriptional regulation of the albumin, collagen, lipoprotein lipase, major histocompatibility complex class II, and a variety of other eukaryotic and viral genes. In this report, the NF-Y complex has been shown to possess histone acetyltransferase activity through physical association with the related histone acetyltransferase enzymes, human GCN5 and P/CAF in vivo. The assembled NF-YA:B:C complex, and the NF-YB:YC, NF-YB:YC (DNA binding-subunit interaction domain), and NF-YC:YB (DNA binding-subunit interaction domain) heterodimers were sufficient to support stable interaction with human GCN5 in vitro, suggesting that these histone acetyltransferases interact with a unique surface in the ancient YB:YC histone-fold motif. Deletion of either N- or C-terminal regions in human GCN5 disrupted interaction with NF-Y in vitro. In addition, human GCN5 was observed to activate NF-Y in transient transfections in vivo using a natural alpha 2(I) collagen pro...Continue Reading

References

May 25, 1992·Nucleic Acids Research·S R HaynesI B Dawid
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G ArentsE N Moudrianakis
Jul 29, 1988·Science·S N MaityB de Crombrugghe
Sep 11, 1987·Cell·A DornD Mathis
Jul 25, 1995·Nucleic Acids Research·A D BaxevanisD Landsman
Apr 1, 1995·Trends in Biochemical Sciences·C L Peterson, J W Tamkun
Jan 6, 1995·The Journal of Biological Chemistry·F CoustryB de Crombrugghe
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·S SinhaB de Crombrugghe
Mar 20, 1995·Molecular & General Genetics : MGG·T GeorgakopoulosG Thireos
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·K van Holde, J Zlatanova
Dec 19, 1996·Nature·A J Bannister, T Kouzarides
Dec 27, 1996·Cell·B R CairnsR D Kornberg

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Citations

Nov 15, 2003·Molecular and Cellular Endocrinology·Michael W CluckThomas E Adrian
Feb 24, 2000·Biochimica Et Biophysica Acta·J ZhangA Fine
Oct 5, 2002·Ageing Research Reviews·Koozi Matuoka, Kuang Yu Chen
Jun 5, 1998·Nucleic Acids Research·E R SmithC D Allis
Nov 1, 2000·Nucleic Acids Research·S ItohP ten Dijke
Sep 28, 2002·Current Opinion in Lipidology·Karina Preiss-LandlRudolf Zechner
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·C MizzenC D Allis
Jul 12, 2011·Cellular and Molecular Life Sciences : CMLS·Chandrasekharan Lalitha IndulekhaJackson James
Mar 3, 2001·Neoplasia : an International Journal for Oncology Research·J Q ZhaoW N Keith
Mar 1, 2003·The Plant Journal : for Cell and Molecular Biology·Mahesh B ChandrasekharanTimothy C Hall
May 12, 2007·Journal of Molecular Biology·Wafa Al-KandariJoseph D Fontes
Aug 9, 2011·The EMBO Journal·Adalberto CostessiHendrik G Stunnenberg

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