PMID: 9186556Apr 1, 1997Paper

NF00659A1, A2, A3, B1 and B2, novel antitumor antibiotics produced by Aspergillus sp. NF 00659. I. Taxonomy, fermentation, isolation and biological activities

The Journal of Antibiotics
K SuzukiT Nakagawa

Abstract

Five novel cytotoxic antibiotics, NF00659A1 (1), A2 (2), A3 (3), B1 (4) and B2 (5) were discovered. They were isolated from a culture mycelium of Aspergillus sp. These compounds were proved to have 4,5-seco-tricyclic diterpene alpha-pyrone structure by spectroscopic analyses. They showed potent antitumor activities against human ovarian carcinoma A2780 and human colorectal adenocarcinoma SW480 cells, but did not show any antimicrobial activities at 1,000 micrograms/ml against Gram-positive and Gram-negative bacteria, yeasts and fungi.

Citations

Mar 11, 2017·Natural Product Research·Xiao-Mei ZhangChun-Hua Lu
Aug 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mengfei YuanWencai Ye
Jul 13, 2005·Natural Product Reports·Gerard P McGlacken, Ian J S Fairlamb
Dec 18, 2007·FEMS Immunology and Medical Microbiology·Denise O GuimarãesMônica T Pupo
Jun 25, 2016·Beilstein Journal of Organic Chemistry·Till F Schäberle
Mar 30, 2018·Journal of Asian Natural Products Research·Wei LaiShi-Hai Xu
Jan 22, 2019·Natural Product Research·Hua ZhangShi-Hai Xu
Mar 6, 2018·Bioorganic & Medicinal Chemistry Letters·Do-Yeon KwonJiyong Hong
Mar 28, 2021·Natural Product Research·Zhonghua YuHaibo Tan
Aug 3, 2021·The Journal of Antibiotics·Kazunari SakaiKenichi Nonaka
Jun 15, 2016·Journal of Natural Products·Haibo ZhangChangsheng Zhang

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