NFκBiz protein downregulation in acute kidney injury: Modulation of inflammation and survival in tubular cells

Biochimica Et Biophysica Acta
Jonay PovedaM Dolores Sánchez-Niño

Abstract

Acute kidney injury is characterized by decreased renal function, tubular cell death and interstitial inflammation. The transcription factor NF-κB is a key regulator of genes involved in cell survival and the inflammatory response. In order to better understand the regulation and role of NF-κB in acute kidney injury we explored the expression of NF-κB-related genes in experimental acute kidney injury induced by a folic acid overdose. NFκBiz, a member of the IκB family of NF-κB regulators encoding NFκBiz, was among the top up-regulated NF-κB-related genes at the mRNA level in experimental acute kidney injury. However, the NFκBiz protein was constitutively expressed by normal tubular cells but was down-regulated in experimental acute kidney injury. Kidney NFκBiz mRNA upregulation and protein downregulation was also observed in acute kidney injury induced by cisplatin or unilateral kidney injury resulting from ureteral obstruction. Thus, we studied the consequences of NFκBiz protein downregulation by specific siRNA in cultured tubular epithelial cells. NFκBiz mRNA and protein were up-regulated by inflammatory cytokines (IL-1β or TWEAK/TNFα/IFNγ) and by LPS in cultured tubular cells. However, TWEAK only induced a very mild and shor...Continue Reading

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Citations

Feb 10, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Beatriz Fernandez-FernandezMaria D Sanchez-Niño
Oct 21, 2016·American Journal of Physiology. Renal Physiology·Olga Ruiz-AndresAlberto Ortiz
Nov 19, 2019·Expert Opinion on Drug Discovery·Adrián M RamosAlberto Ortiz
Feb 23, 2018·Oncotarget·Linlin ChenLing Zhao
May 18, 2019·Clinical Science·Stella BernardiVeronica Tisato
Jul 4, 2018·Drugs·Baris AfsarMehmet Kanbay
Dec 13, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lara Valiño-RivasMaria Dolores Sanchez-Niño
Jan 30, 2021·The Journal of Pathology·Jonay PovedaGema Ruiz-Hurtado
Apr 3, 2021·Molecular and Cellular Endocrinology·Elena Cantero-NavarroAlberto Ortiz
May 4, 2021·Seminars in Cell & Developmental Biology·Raza Ali NaqviAfsar R Naqvi

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