NfL as a biomarker for neurodegeneration and survival in Parkinson disease.

Neurology
David C BäckströmNiklas Lenfeldt

Abstract

To determine whether neurofilament light chain protein in CSF (cNfL), a sensitive biomarker of neuroaxonal damage, reflects disease severity or can predict survival in Parkinson disease (PD). We investigated whether disease severity, phenotype, or survival in patients with new-onset PD correlates with cNfL concentrations around the time of diagnosis in the population-based New Parkinsonism in Umeå (NYPUM) study cohort (n = 99). A second, larger new-onset PD cohort (n = 194) was used for independent validation. Association of brain pathology with the cNfL concentration was examined with striatal dopamine transporter imaging and repeated diffusion tensor imaging at baseline and 1 and 3 years. Higher cNfL in the early phase of PD was associated with greater severity of all cardinal motor symptoms except tremor in both cohorts and with shorter survival and impaired olfaction. cNfL concentrations above the median of 903 ng/L conferred an overall 5.8 times increased hazard of death during follow-up. After adjustment for age and sex, higher cNfL correlated with striatal dopamine transporter uptake deficits and lower fractional anisotropy in diffusion tensor imaging of several axonal tracts. cNfL shows usefulness as a biomarker of dise...Continue Reading

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Citations

Dec 19, 2020·Therapeutic Advances in Neurological Disorders·Chen-Chih ChungChien-Tai Hong
Apr 21, 2021·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·S J G VeenhuisM A A P Willemsen
Jun 22, 2021·Journal of Alzheimer's Disease : JAD·Andrea PilottoAlessandro Padovani
Aug 6, 2021·Molecular Neurobiology·Yareth Gopar-CuevasAracely Garcia-Garcia
Sep 28, 2021·Journal of Neural Transmission·Don Gueu ParkJung Han Yoon

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Methods Mentioned

BETA
ELISA

Software Mentioned

Randomize
FSL
SPSS

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