NGF and LIF both regulate galanin gene expression in primary DRG cultures

Neuroreport
J CornessT Hökfelt

Abstract

Both target-derived and injury-induced factors could be involved in the axotomy-induced increases in galanin expression in dorsal root, ganglion (DRG) neurons. Galanin mRNA levels were studied in primary cultures of E13.5 embryos, grown for 14 days in culture, in response to two candidate molecules, nerve growth factor (NGF) and leukemia inhibitory factor (LIF). In these cultures, NGF withdrawal alone resulted in a significant increase in galanin mRNA. Addition of LIF onto NGF-containing cultures did not produce a significant increase, while addition of LIF to NGF-deprived cultures caused an upregulation of galanin mRNA which was significantly stronger than that of NGF withdrawal alone. Thus, NGF withdrawal and LIF increase act together to up-regulate galanin gene transcription in DRG neurons.

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Citations

Nov 8, 2001·European Journal of Pharmacology·Z Wiesenfeld-Hallin, X J Xu
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Cheil MoonGabriele V Ronnett
Jul 30, 2015·Expert Opinion on Therapeutic Targets·Krista FreimannÜlo Langel
Jul 7, 2011·The Journal of Pain : Official Journal of the American Pain Society·Christina M SpoffordTimothy J Brennan
Feb 1, 2007·Journal of Neurochemistry·Thimmasettappa ThippeswamyJohn P Quinn
Jul 9, 2013·Molecular and Cellular Neurosciences·Michael J Pellegrino, Beth A Habecker
Sep 23, 2014·Neuroscience·A DeFrancesco-LisowitzR E Zigmond
Nov 19, 2020·International Journal of Molecular Sciences·Cecilia Zavala-TecuapetlaHiram Luna-Munguia

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