NGF binding to p75 enhances the sensitivity of sensory and sympathetic neurons to NGF at different stages of development

Molecular and Cellular Neurosciences
A HortonA M Davies

Abstract

To clarify the role of the common neurotrophin receptor p75 in modulating the survival response of sensory and sympathetic neurons to NGF at different stages of development, we compared the actions of wild-type NGF with a mutated NGF protein that binds normally to TrkA, the NGF receptor tyrosine kinase, but has greatly reduced binding to p75. At saturating concentrations, the NGF mutant promoted the survival of similar numbers of trigeminal sensory and sympathetic neurons as NGF. At subsaturating concentrations, the NGF mutant was less effective than wild-type NGF in promoting the survival of embryonic sensory neurons and postnatal sympathetic neurons but was equally effective as wild-type NGF in promoting the survival of embryonic sympathetic neurons. Whereas the levels of trkA and p75 were similar in embryonic sensory neurons and postnatal sympathetic neurons, the level of p75 was significantly lower than that of trkA in embryonic sympathetic neurons. These results indicate that binding of NGF to p75 enhances the sensitivity of NGF-dependent neurons to NGF at stages in their development when the levels of p75 and TrkA are similar.

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Citations

Jan 29, 2000·The Journal of Cell Biology·G MiddletonA M Davies
Aug 8, 2009·Autonomic Neuroscience : Basic & Clinical·Alun M Davies
Mar 24, 2007·Biochemical and Biophysical Research Communications·Na LiHuanying Zhao
Dec 8, 2004·The European Journal of Neuroscience·Kliment P GatzinskyTim Cowen
Jul 16, 2008·Journal of Neurochemistry·Agnes W WongSimon S Murray
Oct 10, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sophia L B OliveiraHenning Ulrich
Jul 22, 2010·International Journal of Cosmetic Science·J A DavisS B Hoath
Feb 27, 2010·Developmental Neurobiology·Leslayann C Schecterson, Mark Bothwell
Dec 4, 2014·CPT: Pharmacometrics & Systems Pharmacology·T ToniP H van der Graaf
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May 29, 2008·Nature Neuroscience·Alun M Davies
Oct 12, 2005·Anatomy and Embryology·Lucía Rodríguez-GallardoGervasio Martín-Partido

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