PMID: 9427507Jan 14, 1998Paper

NGF content and expression in the rat pituitary gland and regulation by thyroid hormone

Brain Research. Molecular Brain Research
L CalzàL Aloe

Abstract

The involvement of nerve growth factor (NGF) in neuroendocrine regulation is supported by several lines of evidence. In this paper, we investigated the NGF content and expression in the pituitary gland and other endocrine organs during dysendocrine states (thyroidectomized, adrenalectomized and gonadectomized male rats). We found an increase of NGF-IR in the pituitary gland and testis of hypothyroid rats whereas no differences were found in the adrenal gland and blood. Also, NGF mRNA expression had increased in the anterior pituitary of hypothyroid rats whereas it had not changed after adrenalectomy and gonadectomy. Moreover, other neurotrophins and neurotrophin high-affinity receptors were unchanged in the anterior pituitary of hypothyroid rats. These data indicate that pituitary NGF is selectively modulated by thyroid status of the animal, further supporting a close link between NGF and thyroid hormone.

References

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Citations

Jul 25, 2009·Archives of Toxicology·Naomi TsukueKen Takeda
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Laura CalzaLuciana Giardino
Jan 5, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefano GovoniEmilio Vanoli
Apr 12, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco AngelucciAleksander A Mathé
Dec 22, 1999·Endocrine Research·M C Amoureux

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