NGF involvement in pain induced by chronic constriction injury of the rat sciatic nerve

Neuroreport
U HerzbergI J Kopin

Abstract

Chronic constriction injury (CCI) of the rat sciatic nerve, which within 3 days induces thermal and mechanical hyperalgesia and mechanical allodynia, is used as a model for pain resulting from nerve injury. Involvement of nerve growth factor (NGF) in the development of this hyperalgesia is suggested by the increase in the level of mRNA encoding NGF in cells in the injured area and in dorsal root ganglia at the level of the lesion and the greatly increased NGF levels (determined by ELISA) in the ganglia ipsilateral to the CCI. Application of anti-serum to NGF at the site of CCI delayed the appearance of hyperalgesia, whereas pre-immune serum appeared to enhance it. These results are consistent with the view that NGF is an important factor in the appearance of hyperalgesia associated with unilateral mononeuropathy.

References

Dec 1, 1994·British Journal of Pharmacology·M Malcangio, N G Bowery
Dec 1, 1994·The European Journal of Neuroscience·G R LewinL M Mendell
Jul 1, 1996·Pain·Natalia Dmitrieva, Stephen B McMahon

❮ Previous
Next ❯

Citations

Feb 16, 2005·Microsurgery·James M KernsMark H Gonzalez
Jun 14, 2001·Current Pain and Headache Reports·A A Larson, K J Kovács
Mar 10, 2005·Experimental Neurology·Stephen B McMahonFabien Marchand
Aug 25, 2006·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·D D AthertonP Anand
Feb 13, 1999·Progress in Neurobiology·M J Millan
Dec 13, 2000·Neuroscience·N M Perkins, D J Tracey
Jan 29, 2000·The European Journal of Neuroscience·X F ZhouJ H Zhong
Sep 3, 2009·The Journal of Biological Chemistry·Guangdun PengNaihe Jing
Jul 20, 2002·Regional Anesthesia and Pain Medicine·Quinn Hogan
Feb 3, 1999·Annals of the New York Academy of Sciences·M S RamerM A Bisby
Jun 17, 2006·Annual Review of Neuroscience·Sophie Pezet, Stephen B McMahon
Feb 7, 2001·Annual Review of Psychology·L R Watkins, S F Maier
Jan 12, 2012·Molecular Pain·Jennifer C Peleshok, Alfredo Ribeiro-da-Silva
Jan 20, 2007·The AAPS Journal·Andrea G Hohmann, Richard L Suplita
Aug 25, 2007·Anesthesia and Analgesia·Michael A ThackerStephen B McMahon
Jan 1, 2008·Anesthesia and Analgesia·Chiyo SatoAtsuhiro Sakamoto
Jul 14, 2005·Biomedical Research·Naoki KitamuraYou Komagiri
Jun 3, 2010·Frontiers in Bioscience (Landmark Edition)·Mark A Schumacher, Helge Eilers
Aug 13, 2013·TheScientificWorldJournal·Marieli Araujo Rossoni MarcioliGladson Ricardo Flor Bertolini
Jan 15, 2008·La Presse médicale·Luis Garcia-Larrea, Michel Magnin
Feb 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gabriele UgoliniFlaminia Pavone
May 2, 2001·Journal of Neurochemistry·M S RamerS B McMahon
Feb 27, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jun ShenJianguo Cheng
Jul 31, 2013·Molecular Pain·Maria OsikowiczAlfredo Ribeiro-da-Silva
Mar 20, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Elliot S Krames
Feb 11, 2015·Molecular and Cellular Neurosciences·Natalia MalekKatarzyna Starowicz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.