PMID: 11327338May 1, 2001Paper

NHE1-inhibitor cariporide prevents the transient reperfusion-induced shortening of the monophasic action potential after coronary ischemia in pigs

Basic Research in Cardiology
K J WirthA E Busch

Abstract

During myocardial ischemia intracellular acid load increases as a consequence of anaerobic metabolism. Exchange of excessive protons for sodium via the sodium proton exchanger type 1 (NHE1) is supposed to cause intracellular sodium accumulation. The NHE1 inhibitor cariporide has been shown to inhibit ischemia and reperfusion-induced ventricular fibrillation (VF) but the mechanisms are not fully understood. During early reperfusion transient shortening of the action potential has been reported, which renders the heart susceptible to reentrant arrhythmias. In anesthetized pigs subjected to 10 min of left circumflex coronary artery (LCX) occlusion and reperfusion we have investigated whether NHE1 is involved in reperfusion-induced shortening of the monophasic action potential (MAP) taken with an epicardial probe over the ischemic area. In control pigs (n = 7) a moderate decrease in the duration of the MAP at 50 % repolarization (MAPD50) occurred during ischemia reaching 78.8 +/- 5.0% of the pre-ischemic duration at 5 min (p < 0.01) and 87.3 +/- 7.6 % after 10 min. An additional, transient but marked shortening occurred during the first 2 min of reperfusion, which fully recovered after 4 min. At 50 sec of reperfusion MAPD50 fell to...Continue Reading

Citations

Feb 5, 2004·The Annals of Thoracic Surgery·Randy M StevensRobert D Lasley
Jul 16, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Dominik LinzHans-Ruprecht Neuberger
Apr 20, 2004·Journal of Cardiovascular Electrophysiology·Yuri BlaauwMaurits A Allessie
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Adam J MoeserAnthony T Blikslager
May 29, 2003·Current Opinion in Critical Care·Raúl J GazmuriJulieta Kolarova
Jun 2, 2020·Frontiers in Pharmacology·Arpad Tosaki
Nov 22, 2019·Frontiers in Cardiovascular Medicine·Stefan Michael SattlerThomas Jespersen

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