NHERF1: molecular brake on the PI3K pathway in breast cancer.

Breast Cancer Research : BCR
Maria-Magdalena Georgescu

Abstract

The adaptor protein NHERF1/EBP50 (Na/H exchanger regulatory factor 1/ezrin-radixin-moesin-binding phosphoprotein 50) emerged recently as an important player in breast cancer progression. Consisting of two tandem PDZ domains linked to a carboxyl-terminal ezrin-binding region, NHERF1 assembles macromolecular complexes at the apical membrane of epithelial cells in many epithelial tissues, including the mammary gland. Involved initially in trafficking and regulation of transmembrane ion transporters and G protein-coupled receptors, NHERF1 also couples molecules involved in cell growth, such as the platelet-derived growth factor receptor (PDGFR) and PTEN (phosphatase and tensin homolog deleted on chromosome 10). In the previous issue of Breast Cancer Research, Pan and colleagues show an inhibitory action of NHERF1 on the phosphoinositide-3 kinase (PI3K)/Akt pathway in breast cancer cells via interaction of NHERF1 with PTEN, the physiological antagonist of the PI3K. Additionally, they show that NHERF1 expression confers susceptibility to PDGFR pharmacological inhibition depending on the presence of PTEN tumor suppressor.

References

Jun 29, 1999·Endocrinology·T R EdigerB S Katzenellenbogen
Aug 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·S ShenolikarE J Weinman
Jun 5, 2004·Developmental Cell·Ichiko SaotomeAndrea I McClatchey
Dec 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fabiana C MoralesMaria-Magdalena Georgescu
Apr 2, 2005·Breast Cancer Research and Treatment·Shanu ModiClifford A Hudis
Jun 18, 2005·The EMBO Journal·Eva MortierPascale Zimmermann
Feb 4, 2006·The EMBO Journal·Yoko TakahashiMaria-Magdalena Georgescu
Nov 3, 2006·Breast Cancer Research : BCR·Yong PanJia Le Dai
Mar 3, 2007·Molecular Biology of the Cell·Rosa A CardoneStephan J Reshkin
Sep 27, 2007·The Journal of Biological Chemistry·James W VoltzShirish Shenolikar

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Citations

Jan 5, 2011·Breast Cancer Research and Treatment·Thomas KarnAchim Rody
Mar 31, 2009·Molecular & Cellular Proteomics : MCP·Arzu UmarLjiljana Pasa-Tolić
Jul 23, 2011·Genes & Cancer·Maria-Magdalena Georgescu
Jun 1, 2010·Cell Communication and Signaling : CCS·Ho-Jin Lee, Jie J Zheng
Nov 23, 2018·The Journal of Biological Chemistry·Jaekwang JeongJohn J Wysolmerski
Feb 27, 2017·The Journal of Biological Chemistry·Jaekwang JeongJohn J Wysolmerski

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