Ni-catalyzed highly chemo-, regio-, and enantioselective decarboxylative aldol reaction of β,γ-unsaturated α-ketoesters with β-ketoacids

The Journal of Organic Chemistry
Ai-Jia WeiJun-An Ma

Abstract

A novel Ni-catalyzed decarboxylative aldol reaction of β,γ-unsaturated α-ketoesters with β-ketoacids is reported. The reaction proceeds smoothly with high chemo-, regio-, and enantioselectivity. This protocol provides a convenient approach to access enantioenriched chiral tertiary alcohols.

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Citations

May 31, 2018·Chemical Society Reviews·Yasuhiro YamashitaShū Kobayashi
Jan 22, 2020·Angewandte Chemie·Connor J ThomsonDarren J Dixon
Jul 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan BojanowskiAnna Albrecht
Sep 4, 2015·Chemistry : a European Journal·Adrien Quintard, Jean Rodriguez
Mar 9, 2021·Chemical Communications : Chem Comm·Sebastian FrankowskiAnna Albrecht
Nov 9, 2021·Organic & Biomolecular Chemistry·Wei QinHongfei Lu

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