Niacin action in the atherogenic mixed dyslipidemia of metabolic syndrome: Insights from metabolic biomarker profiling and network analysis

Journal of Clinical Lipidology
Martin AdielsNiacin Study Group

Abstract

Niacin as an adjunct to statin treatment to reduce cardiovascular risk is questioned. To evaluate interrelationships between the effects of niacin on mixed dyslipidemia and a spectrum of metabolic and inflammatory biomarkers. Obese, nondiabetic, hypertriglyceridemic males (n = 19) with low high-density lipoprotein-cholesterol levels received extended-release nicotinic acid for 8 weeks. Multiple biomarkers were measured using enzyme-linked immunosorbent assay, enzymatic/absorptiometric, or multiplex biochip assays. Treatment effects were determined for each variable and a differential correlation network created on the basis of univariate correlations between baseline and response to niacin treatment for all pairs of variables. Extended-release niacin treatment favoured normalization of plasma lipid and apolipoprotein profile. Plasma markers of inflammation, hepatic function, cellular adhesion and proliferation, and macrophage phenotype were attenuated; however, insulin resistance increased. Differential network analysis revealed that changes in triglycerides and high-density lipoprotein-cholesterol were closely linked; equally, niacin mediated reductions in total cholesterol, apolipoprotein B, low-density lipoprotein-cholestero...Continue Reading

Citations

Oct 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diego Estrada-LunaGabriel Betanzos-Cabrera
May 24, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Massimiliano RuscicaCesare R Sirtori
Jul 3, 2021·Life·Antonina GiammancoAngelo Baldassare Cefalù
Jul 21, 2021·Menopause : the Journal of the North American Menopause Society·Hai Duc Nguyen, Min-Sun Kim

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