Niacin modulates macrophage polarization in Parkinson's disease

Journal of Neuroimmunology
Chandramohan WakadeBabak Baban

Abstract

Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression.

References

Nov 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·K R ChaudhuriC Trenkwalder
Jul 20, 2007·European Journal of Immunology·Banabihari GiriDennis D Taub
Jul 1, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R K Y ChongK Sethi
Jul 14, 2012·Nature Reviews. Drug Discovery·Clara C BladStefan Offermanns
Sep 7, 2012·Cold Spring Harbor Perspectives in Medicine·V Hugh Perry
Aug 28, 2013·Current Opinion in Pharmacology·Vadivel GanapathyNagendra Singh
Oct 17, 2014·Journal of Lipid Research·Kenneth R FeingoldCarl Grunfeld
Oct 21, 2014·PloS One·Chandramohan WakadeJohn Morgan
Dec 3, 2014·Journal of the Neurological Sciences·Chandramohan Wakade, Raymond Chong
Dec 3, 2014·Neuroscience·M S Moehle, A B West
Apr 2, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alexis M StranahanBabak Baban
Feb 17, 2017·Biochemical Society Transactions·Heyne LeeSally A Cowley
Aug 5, 2017·Scientific Reports·Hesham Aly Salem, Walaa Wadie

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Citations

Feb 24, 2019·Reviews in the Neurosciences·Ava NasrolahiJavad Mahmoudi
Oct 17, 2019·Pharmacogenomics·Sony Tuteja
Sep 22, 2019·International Journal of Molecular Sciences·Banabihari GiriChandramohan Wakade
Nov 21, 2019·Scientific Reports·Éva Szentirmai, Levente Kapás
Mar 1, 2019·International Journal of Molecular Sciences·Valeria GasperiMaria Valeria Catani
Jun 4, 2020·International Journal of Molecular Sciences·Estefanía de GregorioMontserrat Marí
Apr 3, 2020·Science Translational Medicine·Susobhan SarkarV Wee Yong
Jan 12, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Leszek RudzkiAgata Szulc
Nov 8, 2020·Nutrients·Christine Tara PetersonScott N Peterson
Nov 7, 2020·Molecular Oral Microbiology·Xiaoyuan GuanHuanxin Meng
Oct 21, 2020·Advanced Drug Delivery Reviews·Sumra NazirEmiel P C van der Vorst
Apr 22, 2021·Metabolic Brain Disease·Banabihari GiriChandramohan Wakade
May 15, 2021·Mechanisms of Ageing and Development·María José PérezMichela Deleidi
Jul 6, 2021·Frontiers in Aging Neuroscience·Raymond ChongSharad Purohit
Aug 1, 2021·American Journal of Reproductive Immunology : AJRI·Alexandra D GoudreauKristi B Adamo

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